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Rfc2 Gene Detail
Summary
  • Symbol
    Rfc2
  • Name
    replication factor C (activator 1) 2
  • Synonyms
    2610008M13Rik, 40kDa, 40kDa, Recc2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341868
    NCBI Gene: 19718
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:134611544-134627182 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 74.68 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    616 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341868
 protein coding gene Chr5:134610220-134630659 (+)
129S1/SvImJ ENSMUSG00200043470
 protein coding gene Chr5:128393001-128412726 (+)
A/J ENSMUSG00195050328
 protein coding gene Chr5:127899817-127919525 (+)
AKR/J ENSMUSG00220048782
 protein coding gene Chr5:127384782-127404488 (+)
BALB/cJ ENSMUSG00180041084
 protein coding gene Chr5:128003753-128023473 (+)
C3H/HeJ ENSMUSG00175039101
 protein coding gene Chr5:129930417-129950142 (+)
C57BL/6NJ ENSMUSG00215045257
 protein coding gene Chr5:128049319-128069045 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027814
 protein coding gene Chr5:127379156-127401609 (+)
CAST/EiJ ENSTCUG00005009309
 protein coding gene Chr5:127272290-127292469 (+)
CBA/J ENSMUSG00210007182
 protein coding gene Chr5:128748114-128767833 (+)
DBA/2J ENSMUSG00185049222
 protein coding gene Chr5:131763265-131782997 (+)
FVB/NJ ENSMUSG00205035209
 protein coding gene Chr5:127652523-127672233 (+)
JF1/MsJ ENSUMUG00000038504
 protein coding gene Chr5:134658483-134678717 (+)
LP/J ENSMUSG00230043407
 protein coding gene Chr5:135877974-135897694 (+)
NOD/ShiLtJ ENSMUSG00190045338
 protein coding gene Chr5:127704747-127724466 (+)
NZO/HlLtJ ENSMUSG00225021919
 protein coding gene Chr5:143558655-143578379 (+)
PWK/PhJ ENSLUMG00010018085
 protein coding gene Chr5:126502272-126522257 (+)
SPRET/EiJ ENSMSPG00010030011
 protein coding gene Chr5:129918292-129934215 (+)
WSB/EiJ ENSIUOG00005033521
 protein coding gene Chr5:130349312-130369017 (+)



Homology
more
  • Human Ortholog
    RFC2, replication factor C subunit 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RFC2, replication factor C subunit 2
  • Synonyms
    RFC40
  • Links
    NCBI Gene ID: 5982
    UniProt: P35250

  • Chr Location
    7q11.23; chr7:74223231-74254458 (-)  GRCh38
Human Diseases
less
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    133
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 19718 NCBI Gene Model | MGI Sequence Detail 15639 C57BL/6J ±  kb
transcript NM_020022 RefSeq | MGI Sequence Detail 1518 Not Specified  
polypeptide Q9WUK4 UniProt | EBI | MGI Sequence Detail 349 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000013906 replication factor C subunit 2
    (term hierarchy)
  • InterPro Domains
    IPR003593 AAA+ ATPase domain
    IPR003959 ATPase, AAA-type, core
    IPR008921 DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal
    IPR050238 DNA Replication and Repair Clamp Loader Complex
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR013748 Replication factor C, C-terminal
    IPR047854 Replication factor C, lid domain
Molecular
Reagents
less
  • All nucleic 138
    Genomic 3
    cDNA 134
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-13826, MGI:1913827, MGI:2140845, MGI:97892
References
more
  • Summaries
    All 61
    Diseases 2
    Gene Ontology 7
    Phenotypes 22
  • Earliest
    J:28599 Burbelo PD, et al., Cloning of the large subunit of activator 1 (replication factor C) reveals homology with bacterial DNA ligases. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11543-7
  • Latest
    J:373971 Gutzen R, et al., A modular and adaptable analysis pipeline to compare slow cerebral rhythms across heterogeneous datasets. Cell Rep Methods. 2024 Jan 22;4(1):100681
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory