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Uba3 Gene Detail
Summary
  • Symbol
    Uba3
  • Name
    ubiquitin-like modifier activating enzyme 3
  • Synonyms
    A830034N06Rik, Ube1c, ubiquitin activating enzyme 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341217
    NCBI Gene: 22200
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:97160631-97182608 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 44.90 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    576 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341217
 protein coding gene Chr6:97160593-97182608 (-)
129S1/SvImJ ENSMUSG00200020457
 protein coding gene Chr6:94155966-94177949 (-)
A/J ENSMUSG00195001920
 protein coding gene Chr6:93853184-93875149 (-)
AKR/J ENSMUSG00220021675
 protein coding gene Chr6:92754114-92776083 (-)
BALB/cJ ENSMUSG00180009310
 protein coding gene Chr6:94237689-94259655 (-)
C3H/HeJ ENSMUSG00175023481
 protein coding gene Chr6:83170435-83192405 (+)
C57BL/6NJ ENSMUSG00215010098
 protein coding gene Chr6:94235339-94257326 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028678
 protein coding gene Chr6:93127010-93149152 (-)
CAST/EiJ ENSTCUG00005001136
 protein coding gene Chr6:94274612-94296463 (-)
CBA/J ENSMUSG00210003664
 protein coding gene Chr6:94039609-94061580 (-)
DBA/2J ENSMUSG00185025679
 protein coding gene Chr6:94518480-94540472 (-)
FVB/NJ ENSMUSG00205010440
 protein coding gene Chr6:93227577-93249541 (-)
JF1/MsJ ENSUMUG00000001332
 protein coding gene Chr6:93424179-93446215 (-)
LP/J ENSMUSG00230011613
 protein coding gene Chr6:95698900-95720881 (-)
NOD/ShiLtJ ENSMUSG00190002596
 protein coding gene Chr6:93683373-93705338 (-)
NZO/HlLtJ ENSMUSG00225038946
 protein coding gene Chr6:97702936-97724918 (-)
PWK/PhJ ENSLUMG00010015380
 protein coding gene Chr6:92868098-92890137 (-)
SPRET/EiJ ENSMSPG00010017783
 protein coding gene Chr6:95247136-95269116 (-)
WSB/EiJ ENSIUOG00005002690
 protein coding gene Chr6:94613256-94635242 (-)



Homology
more
  • Human Ortholog
    UBA3, ubiquitin like modifier activating enzyme 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UBA3, ubiquitin like modifier activating enzyme 3
  • Synonyms
    hUBA3, NAE2, UBE1C
  • Links
    NCBI Gene ID: 9039
    UniProt: Q8TBC4

  • Chr Location
    3p14.1; chr3:69054716-69080408 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants die at the peri-implantation stage. Mutants exhibit selective apoptosis of the inner cell mass but not of trophoblastic cells. Moreover, the trophoblastic cells fail to enter the S phase of the endoreduplication cycle.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    603
  • Tissues
    5
  • cDNA Data
    20
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030061 Ensembl Gene Model | MGI Sequence Detail 21978 C57BL/6J ±  kb
    transcript ENSMUST00000089287 Ensembl | MGI Sequence Detail 2257 Not Applicable  
    polypeptide ENSMUSP00000086701 Ensembl | MGI Sequence Detail 462 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000016952 NEDD8-activating enzyme E1 catalytic subunit
      (term hierarchy)
    • EC
      6.2.1.64
    • InterPro Domains
      IPR014929 E2 binding
      IPR030468 NEDD8-activating enzyme E1 catalytic subunit, N-terminal domain
      IPR045886 ThiF/MoeB/HesA family
      IPR000594 THIF-type NAD/FAD binding fold
      IPR023318 Ubiquitin activating enzyme, alpha domain superfamily
      IPR033127 Ubiquitin-activating enzyme E1, Cys active site
      IPR035985 Ubiquitin-activating enzyme-like
    • GlyGen
      Q8C878 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 21
      Antibodies 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1353580, MGI:2141496, MGI:2141693, MGI:2441832
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 2
      Gene Ontology 11
      Phenotypes 20
    • Earliest
      J:54622 Gong L, et al., Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway. J Biol Chem. 1999 Apr 23;274(17):12036-42
    • Latest
      J:387855 Ahmed AA, et al., NEDDylation maintains oocyte quality by stabilizing mitochondrial transcription. Sci Adv. 2026 Jun 19;12(25):eaec3505
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory