About   Help   FAQ
Ier5 Gene Detail
Summary
  • Symbol
    Ier5
  • Name
    immediate early response 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1337072
    NCBI Gene: 15939
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:154972113-154975382 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 66.45 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    75 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1337072
 protein coding gene Chr1:154972107-154975382 (-)
129S1/SvImJ ENSMUSG00200002431
 protein coding gene Chr1:152414926-152418201 (-)
A/J ENSMUSG00195013879
 protein coding gene Chr1:151802929-151806204 (-)
AKR/J ENSMUSG00220004904
 protein coding gene Chr1:151602165-151605440 (-)
BALB/cJ ENSMUSG00180029373
 protein coding gene Chr1:152022233-152025508 (-)
C3H/HeJ ENSMUSG00175002582
 protein coding gene Chr1:152061381-152064656 (-)
C57BL/6NJ ENSMUSG00215003381
 protein coding gene Chr1:151957881-151961156 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014721
 protein coding gene Chr1:145801327-145804634 (-)
CAST/EiJ ENSTCUG00005005675
 protein coding gene Chr1:150598842-150602115 (-)
CBA/J ENSMUSG00210030624
 protein coding gene Chr1:151964847-151968122 (-)
DBA/2J ENSMUSG00185040151
 protein coding gene Chr1:156234882-156238155 (-)
FVB/NJ ENSMUSG00205026623
 protein coding gene Chr1:151097172-151100447 (-)
JF1/MsJ ENSUMUG00000016741
 protein coding gene Chr1:155398014-155401289 (-)
LP/J ENSMUSG00230015155
 protein coding gene Chr1:155791565-155794844 (-)
NOD/ShiLtJ ENSMUSG00190012162
 protein coding gene Chr1:151812974-151816249 (-)
NZO/HlLtJ ENSMUSG00225005174
 protein coding gene Chr1:159478063-159481338 (-)
PWK/PhJ ENSLUMG00010026800
 protein coding gene Chr1:150748192-150751467 (-)
SPRET/EiJ ENSMSPG00010037735
 protein coding gene Chr1:154088522-154091801 (-)
WSB/EiJ ENSIUOG00005021805
 protein coding gene Chr1:151373508-151376784 (-)



Homology
more
  • Human Ortholog
    IER5, immediate early response 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IER5, immediate early response 5
  • Synonyms
    SBBI48
  • Links
    NCBI Gene ID: 51278
    UniProt: Q5VY09

  • Chr Location
    1q25.3; chr1:181088700-181092900 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    6
  • Genomic Mutations
    2 involving Ier5
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    15 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    653
  • Tissues
    38
  • cDNA Data
    144
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 15939 NCBI Gene Model | MGI Sequence Detail 3270 C57BL/6J ±  kb
transcript NM_010500 RefSeq | MGI Sequence Detail 3272 ZRU/MplStud  
polypeptide O89113 UniProt | EBI | MGI Sequence Detail 308 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 147
    Genomic 2
    cDNA 144
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 36
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:53195 Williams M, et al., Ier5, a novel member of the slow-kinetics immediate-early genes. Genomics. 1999 Feb 1;55(3):327-34
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory