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Mrpl22 Gene Detail
Summary
  • Symbol
    Mrpl22
  • Name
    mitochondrial ribosomal protein L22
  • Synonyms
    E030011D16Rik, HSPC158, MRP-L25, Rpml25
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333794
    NCBI Gene: 216767
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:58062487-58070391 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 35.89 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    67 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333794
 protein coding gene Chr11:58060850-58070406 (+)
129S1/SvImJ ENSMUSG00200035094
 protein coding gene Chr11:55061630-55069543 (+)
A/J ENSMUSG00195034903
 protein coding gene Chr11:54995738-55003651 (+)
AKR/J ENSMUSG00220037889
 protein coding gene Chr11:55157979-55165892 (+)
BALB/cJ ENSMUSG00180048083
 protein coding gene Chr11:55077997-55085911 (+)
C3H/HeJ ENSMUSG00175047710
 protein coding gene Chr11:55030790-55038702 (+)
C57BL/6NJ ENSMUSG00215039071
 protein coding gene Chr11:54852481-54860385 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016386
 protein coding gene Chr11:53008940-53016799 (+)
CAST/EiJ ENSTCUG00005039709
 protein coding gene Chr11:54569971-54577878 (+)
CBA/J ENSMUSG00210028049
 protein coding gene Chr11:54882422-54890334 (+)
DBA/2J ENSMUSG00185037242
 protein coding gene Chr11:55067297-55075209 (+)
FVB/NJ ENSMUSG00205041080
 protein coding gene Chr11:54935182-54943095 (+)
JF1/MsJ ENSUMUG00000023963
 protein coding gene Chr11:55415202-55423107 (+)
LP/J ENSMUSG00230044335
 protein coding gene Chr11:56265208-56277709 (+)
NOD/ShiLtJ ENSMUSG00190031185
 protein coding gene Chr11:55121284-55129196 (+)
NZO/HlLtJ ENSMUSG00225032466
 protein coding gene Chr11:58280889-58293390 (+)
PWK/PhJ ENSLUMG00010027644
 protein coding gene Chr11:54874154-54882012 (+)
SPRET/EiJ ENSMSPG00010028176
 protein coding gene Chr11:55660914-55668792 (+)
WSB/EiJ ENSIUOG00005030433
 protein coding gene Chr11:54924095-54932007 (+)



Homology
more
  • Human Ortholog
    MRPL22, mitochondrial ribosomal protein L22
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MRPL22, mitochondrial ribosomal protein L22
  • Synonyms
    HSPC158, L22mt, MRP-L22, MRP-L25, RPML25, uL22m
  • Links
    NCBI Gene ID: 29093
    UniProt: Q9NWU5

  • Chr Location
    5q33.2; chr5:154941073-154969411 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 1 allele in 2 genetic backgrounds
    1 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased embryo size, a rudimentary egg cylinder, failure of primitive streak formation, absent primitive node and head folds, failure to gastrulate, abnormal mitochondrial morphology and physiology, and complete lethality prior to organogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    700
  • Tissues
    57
  • cDNA Data
    61
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020514 Ensembl Gene Model | MGI Sequence Detail 7905 C57BL/6J ±  kb
    transcript ENSMUST00000020820 Ensembl | MGI Sequence Detail 722 Not Applicable  
    polypeptide ENSMUSP00000020820 Ensembl | MGI Sequence Detail 206 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 65
      cDNA 61
      Primer pair 4

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:2442655
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 5
      Gene Ontology 9
      Phenotypes 13
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory