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Lin7c Gene Detail
Summary
  • Symbol
    Lin7c
  • Name
    lin-7 homolog C, crumbs cell polarity complex component
  • Synonyms
    9130007B12Rik, D2Ertd520e, LIN-7-C, Lin7c, LIN-7C, MALS-3, Veli3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330839
    NCBI Gene: 22343
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:109721205-109731348 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 56.65 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    336 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330839
 protein coding gene Chr2:109721198-109731348 (+)
129S1/SvImJ ENSMUSG00200007285
 protein coding gene Chr2:106606368-106616516 (+)
A/J ENSMUSG00195028039
 protein coding gene Chr2:106675428-106685571 (+)
AKR/J ENSMUSG00220004534
 protein coding gene Chr2:106507016-106517158 (+)
BALB/cJ ENSMUSG00180032818
 protein coding gene Chr2:106470637-106480780 (+)
C3H/HeJ ENSMUSG00175029074
 protein coding gene Chr2:106880836-106891084 (+)
C57BL/6NJ ENSMUSG00215020419
 protein coding gene Chr2:106611516-106621667 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024048
 protein coding gene Chr2:103100092-103110898 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210035301
 protein coding gene Chr2:106748086-106758229 (+)
DBA/2J ENSMUSG00185036677
 protein coding gene Chr2:106467040-106477183 (+)
FVB/NJ ENSMUSG00205014000
 protein coding gene Chr2:105799446-105809590 (+)
JF1/MsJ ENSUMUG00000001363
 protein coding gene Chr2:106283466-106293707 (+)
LP/J ENSMUSG00230005133
 protein coding gene Chr2:108268767-108278915 (+)
NOD/ShiLtJ ENSMUSG00190015194
 protein coding gene Chr2:106694054-106704202 (+)
NZO/HlLtJ ENSMUSG00225012272
 protein coding gene Chr2:116168706-116178854 (+)
PWK/PhJ ENSLUMG00010002923
 protein coding gene Chr2:106294205-106304454 (+)
SPRET/EiJ ENSMSPG00010031307
 protein coding gene Chr2:108462511-108474727 (+)
WSB/EiJ ENSIUOG00005029813
 protein coding gene Chr2:106335429-106345573 (+)



Homology
more
  • Human Ortholog
    LIN7C, lin-7 cell polarity scaffold C
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LIN7C, lin-7 cell polarity scaffold C
  • Synonyms
    LIN-7-C, LIN-7C, MALS-3, MALS3, VELI3
  • Links
    NCBI Gene ID: 55327
    UniProt: Q9NUP9

  • Chr Location
    11p14.1; chr11:27494418-27506769 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    4 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted disruption of this gene appears to have no phenotype, but when combined with Lin7a or Lin7a and Lin7b results in early postnatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    634
  • Tissues
    12
  • cDNA Data
    25
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22343 NCBI Gene Model | MGI Sequence Detail 10144 C57BL/6J ±  kb
    transcript NM_011699 RefSeq | MGI Sequence Detail 4221 ZRU/MplStud  
    polypeptide O88952 UniProt | EBI | MGI Sequence Detail 197 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 25
      Primer pair 3
      Antibodies 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1261877, MGI:1918822, MGI:2138876, MGI:2139174, MGI:2139318
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 7
      Gene Ontology 10
      Phenotypes 12
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:209053 Hoekstra EJ, et al., Lmx1a is an activator of Rgs4 and Grb10 and is responsible for the correct specification of rostral and medial mdDA neurons. Eur J Neurosci. 2013 Jan;37(1):23-32
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory