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Tcap Gene Detail
Summary
  • Symbol
    Tcap
  • Name
    titin-cap
  • Synonyms
    Telethonin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330233
    NCBI Gene: 21393
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:98274637-98275779 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 61.75 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    121 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330233
 protein coding gene Chr11:98274637-98275779 (+)
129S1/SvImJ ENSMUSG00200051510
 protein coding gene Chr11:95529647-95530789 (+)
A/J ENSMUSG00195052105
 protein coding gene Chr11:95244724-95245866 (+)
AKR/J ENSMUSG00220049330
 protein coding gene Chr11:95503826-95504968 (+)
BALB/cJ ENSMUSG00180049006
 protein coding gene Chr11:95516508-95517650 (+)
C3H/HeJ ENSMUSG00175048199
 protein coding gene Chr11:95503250-95504392 (+)
C57BL/6NJ ENSMUSG00215051888
 protein coding gene Chr11:95092788-95093930 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017081
 protein coding gene Chr11:94170187-94171332 (+)
CAST/EiJ ENSTCUG00005045487
 protein coding gene Chr11:94955934-94957076 (+)
CBA/J ENSMUSG00210052307
 protein coding gene Chr11:95206761-95207903 (+)
DBA/2J ENSMUSG00185049844
 protein coding gene Chr11:95553161-95554303 (+)
FVB/NJ ENSMUSG00205045348
 protein coding gene Chr11:95420067-95421209 (+)
JF1/MsJ ENSUMUG00000054085
 protein coding gene Chr11:95859157-95860299 (+)
LP/J ENSMUSG00230047248
 protein coding gene Chr11:96606067-96607209 (+)
NOD/ShiLtJ ENSMUSG00190035305
 protein coding gene Chr11:95594471-95595613 (+)
NZO/HlLtJ ENSMUSG00225051626
 protein coding gene Chr11:98658104-98659246 (+)
PWK/PhJ ENSLUMG00010050939
 protein coding gene Chr11:95410783-95411925 (+)
SPRET/EiJ ENSMSPG00010049650
 protein coding gene Chr11:95903249-95904390 (+)
WSB/EiJ ENSIUOG00005047563
 protein coding gene Chr11:95359560-95360702 (+)



Homology
more
  • Human Ortholog
    TCAP, titin-cap
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TCAP, titin-cap
  • Synonyms
    CMD1N, CMH25, LGMD2G, LGMDR7, T-cap, TELE, telethonin
  • Links
    NCBI Gene ID: 8557
    UniProt: O15273

  • Chr Location
    17q12; chr17:39665349-39666554 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tcap mouse models; 2 with human TCAP associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 3 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit skeletal muscle atrophy, myopathy, increased muscle stiffness, and impaired coordination. Mice homozygous for another knock-out allele exhibit increased response to transverse aortic constriction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    69
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    614
  • Tissues
    15
  • cDNA Data
    46
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21393 NCBI Gene Model | MGI Sequence Detail 1143 C57BL/6J ±  kb
    transcript NM_011540 RefSeq | MGI Sequence Detail 948 Not Specified  
    polypeptide O70548 UniProt | EBI | MGI Sequence Detail 167 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 46
      Primer pair 1
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2144206, MGI:2144337
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 8
      Phenotypes 11
    • Earliest
      J:51067 Gregorio CC, et al., The NH2 terminus of titin spans the Z-disc: its interaction with a novel 19-kD ligand (T-cap) is required for sarcomeric integrity. J Cell Biol. 1998 Nov 16;143(4):1013-27
    • Latest
      J:375899 Hanashima A, et al., CCDC141 is a Connectin/Titin and Nesprin-1 binding protein that adapts cardiomyocytes to mechanical stress. Commun Biol. 2025 Nov 26;8(1):1693
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory