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Rngtt Gene Detail
Summary
  • Symbol
    Rngtt
  • Name
    RNA guanylyltransferase and 5'-phosphatase
  • Synonyms
    Mce1, mouse capping enzyme
  • Feature Type
    protein coding gene
  • IDs
    MGI:1329041
    NCBI Gene: 24018
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:33310311-33502614 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 14.78 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4493 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1329041
 protein coding gene Chr4:33310300-33502614 (+)
129S1/SvImJ ENSMUSG00200012085
 protein coding gene Chr4:30006419-30198945 (+)
A/J ENSMUSG00195002719
 protein coding gene Chr4:30525802-30718329 (+)
AKR/J ENSMUSG00220014286
 protein coding gene Chr4:30318106-30512519 (+)
BALB/cJ ENSMUSG00180000143
 protein coding gene Chr4:30028885-30221396 (+)
C3H/HeJ ENSMUSG00175002273
 protein coding gene Chr4:30500650-30695068 (+)
C57BL/6NJ ENSMUSG00215000787
 protein coding gene Chr4:30112509-30305068 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025875
 protein coding gene Chr4:27882437-28073468 (+)
CAST/EiJ ENSTCUG00005000305
 protein coding gene Chr4:30010080-30201126 (+)
CBA/J ENSMUSG00210004424
 protein coding gene Chr4:30225270-30419650 (+)
DBA/2J ENSMUSG00185000245
 protein coding gene Chr4:30297714-30492096 (+)
FVB/NJ ENSMUSG00205000375
 protein coding gene Chr4:29882904-30077284 (+)
JF1/MsJ ENSUMUG00000001440
 protein coding gene Chr4:30335221-30526090 (+)
LP/J ENSMUSG00230000879
 protein coding gene Chr4:33584126-33776681 (+)
NOD/ShiLtJ ENSMUSG00190000209
 protein coding gene Chr4:30222037-30414543 (+)
NZO/HlLtJ ENSMUSG00225008442
 protein coding gene Chr4:37527478-37720021 (+)
PWK/PhJ ENSLUMG00010007417
 protein coding gene Chr4:29786488-29978849 (+)
SPRET/EiJ ENSMSPG00010020526
 protein coding gene Chr4:30623148-30812345 (+)
WSB/EiJ ENSIUOG00005004797
 protein coding gene Chr4:30030551-30222215 (+)



Homology
more
  • Human Ortholog
    RNGTT, RNA guanylyltransferase and 5'-phosphatase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RNGTT, RNA guanylyltransferase and 5'-phosphatase
  • Synonyms
    CAP1A, hCAP, HCE, HCE1
  • Links
    NCBI Gene ID: 8732
    UniProt: O60942

  • Chr Location
    6q15; chr6:88609897-88963626 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    607
  • Tissues
    10
  • cDNA Data
    17
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028274 Ensembl Gene Model | MGI Sequence Detail 192304 C57BL/6J ±  kb
transcript ENSMUST00000108153 Ensembl | MGI Sequence Detail 4157 Not Applicable  
polypeptide ENSMUSP00000103788 Ensembl | MGI Sequence Detail 597 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    cDNA 19

    Microarray probesets 4
Other
Accession IDs
less
MGI:2140461
References
more
  • Summaries
    All 49
    Developmental Gene Expression 2
    Gene Ontology 12
    Phenotypes 10
  • Earliest
    J:50704 McCracken S, et al., 5'-Capping enzymes are targeted to pre-mRNA by binding to the phosphorylated carboxy-terminal domain of RNA polymerase II [see comments]. Genes Dev. 1997 Dec 15;11(24):3306-18
  • Latest
    J:388794 Gayen A, et al., The mRNA-capping enzyme localizes to stress granules in the cytoplasm and maintains cap homeostasis of target mRNAs. J Cell Sci. 2024 Jun 1;137(11):jcs261578
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory