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Rad9a Gene Detail
Summary
  • Symbol
    Rad9a
  • Name
    RAD9 checkpoint clamp component A
  • Synonyms
    Rad9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1328356
    NCBI Gene: 19367
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:4245195-4251661 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 3.89 cM, cytoband A
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    86 from dbSNP Build 142
  • Strain Annotations
    26
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1328356
 protein coding gene Chr19:4245195-4251710 (-)
129S1/SvImJ ENSMUSGG00200055020
 protein coding gene Chr19:1007689-1008107 (-)
129S1/SvImJ ENSMUSG00200050996
 protein coding gene Chr19:1008246-1012148 (-)
A/J ENSMUSG00195051897
 protein coding gene Chr19:1399493-1403395 (-)
A/J ENSMUSGG00195055561
 protein coding gene Chr19:1398936-1399354 (-)
AKR/J ENSMUSG00220043666
 protein coding gene Chr19:1172426-1176328 (-)
AKR/J ENSMUSGG00220054976
 protein coding gene Chr19:1171869-1172287 (-)
BALB/cJ ENSMUSG00180046198
 protein coding gene Chr19:1774238-1778140 (-)
BALB/cJ ENSMUSGG00180055644
 protein coding gene Chr19:1773681-1774099 (-)
C3H/HeJ ENSMUSG00175009713
 protein coding gene Chr19:1018968-1022870 (-)
C3H/HeJ ENSMUSGG00175055191
 protein coding gene Chr19:1018411-1018829 (-)
C57BL/6NJ ENSMUSGG00215055861
 protein coding gene Chr19:1245997-1246415 (-)
C57BL/6NJ ENSMUSG00215043221
 protein coding gene Chr19:1246554-1250456 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022499
 protein coding gene Chr19:940444-947044 (-)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210055094
 protein coding gene Chr19:1018711-1019129 (-)
CBA/J ENSMUSG00210033668
 protein coding gene Chr19:1019268-1023170 (-)
DBA/2J ENSMUSGG00185057999
 protein coding gene Chr19:1395021-1395439 (-)
DBA/2J ENSMUSG00185041136
 protein coding gene Chr19:1395578-1399480 (-)
FVB/NJ ENSMUSGG00205054718
 protein coding gene Chr19:1396142-1396560 (-)
FVB/NJ ENSMUSG00205050447
 protein coding gene Chr19:1396699-1400601 (-)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055923
 protein coding gene Chr19:2313853-2314271 (-)
LP/J ENSMUSG00230052072
 protein coding gene Chr19:2314410-2318312 (-)
NOD/ShiLtJ ENSMUSGG00190055160
 protein coding gene Chr19:940014-940432 (-)
NOD/ShiLtJ ENSMUSG00190030419
 protein coding gene Chr19:940571-944473 (-)
NZO/HlLtJ ENSMUSG00225025772
 protein coding gene Chr19:6023259-6027161 (-)
NZO/HlLtJ ENSMUSGG00225055568
 protein coding gene Chr19:6022702-6023120 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    RAD9A, RAD9 checkpoint clamp component A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAD9A, RAD9 checkpoint clamp component A
  • Synonyms
    RAD9
  • Links
    NCBI Gene ID: 5883
    UniProt: Q99638

  • Chr Location
    11q13.2; chr11:67317871-67398412 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 3 alleles in 3 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a knock-out allele are consistently smaller and display abnormal embryonic development and midgestational lethality associated with increased apoptosis and reduced cellular proliferation. Mutant mouse embryonic fibroblasts are not viable.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    627
  • Tissues
    21
  • cDNA Data
    50
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024824 Ensembl Gene Model | MGI Sequence Detail 6467 C57BL/6J ±  kb
    transcript ENSMUST00000025740 Ensembl | MGI Sequence Detail 2081 Not Applicable  
    polypeptide ENSMUSP00000025740 Ensembl | MGI Sequence Detail 389 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 54
      Genomic 1
      cDNA 50
      Primer pair 3

      Microarray probesets 4
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 6
      Gene Ontology 10
      Phenotypes 20
    • Earliest
      J:50019 Richter MF, et al., Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1. J Biol Chem. 1998 Sep 18;273(38):24723-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory