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Cdc7 Gene Detail
Summary
  • Symbol
    Cdc7
  • Name
    cell division cycle 7
  • Synonyms
    Cdc7, Cdc7l1, muCdc7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1309511
    NCBI Gene: 12545
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:107112201-107132298 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 51.43 cM, cytoband E
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    558 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1309511
 protein coding gene Chr5:107112188-107132298 (+)
129S1/SvImJ ENSMUSG00200005996
 protein coding gene Chr5:100848204-100868314 (+)
A/J ENSMUSG00195032162
 protein coding gene Chr5:100318174-100338273 (+)
AKR/J ENSMUSG00220032207
 protein coding gene Chr5:99866863-99886974 (+)
BALB/cJ ENSMUSG00180030335
 protein coding gene Chr5:100470306-100490406 (+)
C3H/HeJ ENSMUSG00175046680
 protein coding gene Chr5:102507270-102527365 (+)
C57BL/6NJ ENSMUSG00215016372
 protein coding gene Chr5:100514989-100535101 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027497
 protein coding gene Chr5:99861619-99881606 (+)
CAST/EiJ ENSTCUG00005022970
 protein coding gene Chr5:99732460-99752626 (+)
CBA/J ENSMUSG00210033511
 protein coding gene Chr5:101264854-101284949 (+)
DBA/2J ENSMUSG00185041357
 protein coding gene Chr5:104164644-104184732 (+)
FVB/NJ ENSMUSG00205027565
 protein coding gene Chr5:100192042-100212137 (+)
JF1/MsJ ENSUMUG00000009788
 protein coding gene Chr5:107217762-107237930 (+)
LP/J ENSMUSG00230028658
 protein coding gene Chr5:108389327-108409437 (+)
NOD/ShiLtJ ENSMUSG00190023342
 protein coding gene Chr5:100176510-100196597 (+)
NZO/HlLtJ ENSMUSG00225025678
 protein coding gene Chr5:116011176-116031285 (+)
PWK/PhJ ENSLUMG00010015106
 protein coding gene Chr5:99217400-99237475 (+)
SPRET/EiJ ENSMSPG00010042973
 protein coding gene Chr5:102306615-102326994 (+)
WSB/EiJ ENSIUOG00005036442
 protein coding gene Chr5:102889609-102909701 (+)



Homology
more
  • Human Ortholog
    CDC7, cell division cycle 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDC7, cell division cycle 7
  • Synonyms
    CDC7L1, HsCDC7, Hsk1, huCDC7
  • Links
    NCBI Gene ID: 8317
    UniProt: O00311

  • Chr Location
    1p22.1; chr1:91500535-91527360 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 3 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in embryonic lethality between E3.5-E6.5. In conjunction with a Trp53-null allele, double homozygous mutant embryos survive up to E8.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    758
  • Tissues
    41
  • cDNA Data
    53
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12545 NCBI Gene Model | MGI Sequence Detail 20098 C57BL/6J ±  kb
    transcript NM_001271566 RefSeq | MGI Sequence Detail 3131 C57BL/6  
    polypeptide Q9Z0H0 UniProt | EBI | MGI Sequence Detail 564 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 59
      Genomic 3
      cDNA 53
      Primer pair 3
      Antibodies 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2140941
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 9
      Gene Ontology 8
      Phenotypes 24
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:388027 Wang W, et al., CCDC174 deficiency impaired human fertility by affecting the alternative splicing of maternal mRNAs. EMBO Mol Med. 2026 Jun;18(6):2436-2454
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory