About   Help   FAQ
Tspan7 Gene Detail
Summary
  • Symbol
    Tspan7
  • Name
    tetraspanin 7
  • Synonyms
    1200014P11Rik, A15, Cd231, PE31, TALLA, Tm4sf2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298407
    NCBI Gene: 21912
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:10351397-10462844 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 4.85 cM, cytoband A1.3-A2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2330 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1298407
 protein coding gene ChrX:10351355-10462844 (+)
129S1/SvImJ ENSMUSG00200033198
 protein coding gene ChrX:5110747-5222145 (+)
A/J ENSMUSG00195038307
 protein coding gene ChrX:5071592-5183054 (+)
AKR/J ENSMUSG00220029409
 protein coding gene ChrX:4611636-4725900 (+)
BALB/cJ ENSMUSG00180029358
 protein coding gene ChrX:5069297-5180740 (+)
C3H/HeJ ENSMUSG00175030363
 protein coding gene ChrX:5097754-5209152 (+)
C57BL/6NJ ENSMUSG00215038176
 protein coding gene ChrX:5742050-5853513 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032933
 protein coding gene ChrX:4396413-4498706 (+)
CAST/EiJ ENSTCUG00005030849
 protein coding gene ChrX:5065504-5169142 (+)
CBA/J ENSMUSG00210037917
 protein coding gene ChrX:5140644-5252040 (+)
DBA/2J ENSMUSG00185035246
 protein coding gene ChrX:11733068-11844463 (+)
FVB/NJ ENSMUSG00205021376
 protein coding gene ChrX:4816923-4931849 (+)
JF1/MsJ ENSUMUG00000020129
 protein coding gene ChrX:25591397-25697118 (+)
LP/J ENSMUSG00230031966
 protein coding gene ChrX:16300530-16411919 (+)
NOD/ShiLtJ ENSMUSG00190031701
 protein coding gene ChrX:5096702-5208149 (+)
NZO/HlLtJ ENSMUSG00225033439
 protein coding gene ChrX:21518857-21630240 (+)
PWK/PhJ ENSLUMG00010032062
 protein coding gene ChrX:5005863-5110201 (+)
SPRET/EiJ ENSMSPG00010022667
 protein coding gene ChrX:5939918-6043967 (+)
WSB/EiJ ENSIUOG00005016533
 protein coding gene ChrX:1790515-1902185 (+)



Homology
more
  • Human Ortholog
    TSPAN7, tetraspanin 7
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TSPAN7, tetraspanin 7
  • Synonyms
    A15, CCG-B7, CD231, DXS1692E, MRX58, MXS1, TALLA-1, TM4SF2, TM4SF2b, XLID58
  • Links
    NCBI Gene ID: 7102
    UniProt: P41732

  • Chr Location
    Xp11.4; chrX:38561498-38689249 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TSPAN7 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit altered hippocampal neurons, reduced mEPSC amplitudes and frequencies, reduced long term potentiation, reduced recognition of novel objects, impaired spatial working memory and spatial learning, and impaired associative memory.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    820
  • Tissues
    59
  • cDNA Data
    154
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000058254 Ensembl Gene Model | MGI Sequence Detail 111448 C57BL/6J ±  kb
    transcript ENSMUST00000076354 Ensembl | MGI Sequence Detail 1733 Not Applicable  
    polypeptide ENSMUSP00000075692 Ensembl | MGI Sequence Detail 249 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 154
      cDNA 154

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1923526, MGI:2147872, MGI:2148083
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 9
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:49742 Kuroiwa A, et al., Comparative FISH mapping of mouse and rat homologues of twenty-five human X-linked genes. Cytogenet Cell Genet. 1998;81(3-4):208-12
    • Latest
      J:368549 Nemoto S, et al., Tetraspanin7 in adipose tissue remodeling and its impact on metabolic health. Mol Metab. 2025 Jul;97:102168
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory