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Pcm1 Gene Detail
Summary
  • Symbol
    Pcm1
  • Name
    pericentriolar material 1
  • Synonyms
    2600002H09Rik, 9430077F19Rik, C030044G17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277958
    NCBI Gene: 18536
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:41692789-41785381 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 23.89 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1397 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277958
 protein coding gene Chr8:41692521-41787125 (+)
129S1/SvImJ ENSMUSG00200007364
 protein coding gene Chr8:36744286-36845068 (+)
A/J ENSMUSG00195005540
 protein coding gene Chr8:37236304-37337186 (+)
AKR/J ENSMUSG00220005336
 protein coding gene Chr8:37041223-37142125 (+)
BALB/cJ ENSMUSG00180003142
 protein coding gene Chr8:36781064-36881940 (+)
C3H/HeJ ENSMUSG00175014297
 protein coding gene Chr8:36959011-37059910 (+)
C57BL/6NJ ENSMUSG00215006276
 protein coding gene Chr8:36764805-36868587 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031004
 protein coding gene Chr8:35199502-35291522 (+)
CAST/EiJ ENSTCUG00005005444
 protein coding gene Chr8:36869727-36969919 (+)
CBA/J ENSMUSG00210012633
 protein coding gene Chr8:36799204-36900078 (+)
DBA/2J ENSMUSG00185005527
 protein coding gene Chr8:42699745-42800649 (+)
FVB/NJ ENSMUSG00205002290
 protein coding gene Chr8:35954414-36055311 (+)
JF1/MsJ ENSUMUG00000007444
 protein coding gene Chr8:44425743-44529497 (+)
LP/J ENSMUSG00230009208
 protein coding gene Chr8:46349436-46450306 (+)
NOD/ShiLtJ ENSMUSG00190015476
 protein coding gene Chr8:36820008-36920908 (+)
NZO/HlLtJ ENSMUSG00225014529
 protein coding gene Chr8:49987143-50088812 (+)
PWK/PhJ ENSLUMG00010012273
 protein coding gene Chr8:36649449-36745758 (+)
SPRET/EiJ ENSMSPG00010004398
 protein coding gene Chr8:37498635-37590994 (+)
WSB/EiJ ENSIUOG00005005512
 protein coding gene Chr8:37684564-37785153 (+)



Homology
more
  • Human Ortholog
    PCM1, pericentriolar material 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PCM1, pericentriolar material 1
  • Synonyms
    PTC4, RET/PCM-1
  • Links
    NCBI Gene ID: 5108
    UniProt: Q15154

  • Chr Location
    8p22; chr8:17922746-18029996 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Haploinsufficient mice show a reduced brain size, behavioral impairment to social stimulus and reduced rearing in the open field test.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    75
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    603
  • Tissues
    3
  • cDNA Data
    17
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031592 Ensembl Gene Model | MGI Sequence Detail 92593 C57BL/6J ±  kb
    transcript ENSMUST00000211247 Ensembl | MGI Sequence Detail 6484 Not Applicable  
    polypeptide ENSMUSP00000147887 Ensembl | MGI Sequence Detail 2064 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000012419 pericentriolar material 1 protein
      (term hierarchy)
    • InterPro Domains
      IPR024138 Pericentriolar material 1 protein
      IPR031446 Pericentriolar material 1 protein, C-terminal
    • GlyGen
      Q9R0L6 12 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (10 sites)
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 1
      cDNA 18
      Primer pair 1
      Antibodies 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1919589, MGI:1924673, MGI:1924736
    References
    more
    • Summaries
      All 77
      Developmental Gene Expression 15
      Gene Ontology 22
      Phenotypes 19
    • Earliest
      J:28401 Bettenhausen B, et al., Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Genomics. 1995 Aug 10;28(3):436-41
    • Latest
      J:371501 Pimentel L, et al., Centriolar protein PIBF1 is required for craniofacial and forebrain development. Dev Biol. 2025 Aug 5;527:55-64
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory