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Pde8a Gene Detail
Summary
  • Symbol
    Pde8a
  • Name
    phosphodiesterase 8A
  • Synonyms
    Pde8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277116
    NCBI Gene: 18584
  • Alliance
    genome feature page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:80863344-80984281 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 45.71 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2965 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277116
 protein coding gene Chr7:80863013-80984283 (+)
129S1/SvImJ ENSMUSG00200031732
 protein coding gene Chr7:67682809-67803811 (+)
A/J ENSMUSG00195036304
 protein coding gene Chr7:72106273-72227615 (+)
AKR/J ENSMUSG00220031584
 protein coding gene Chr7:65641158-65762486 (+)
BALB/cJ ENSMUSG00180013244
 protein coding gene Chr7:68824201-68945535 (+)
C3H/HeJ ENSMUSG00175021492
 protein coding gene Chr7:69594890-69715894 (+)
C57BL/6NJ ENSMUSG00215024627
 protein coding gene Chr7:68690993-68811939 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029917
 protein coding gene Chr7:83783736-83906381 (+)
CAST/EiJ ENSTCUG00005040681
 protein coding gene Chr7:72157202-72278787 (+)
CBA/J ENSMUSG00210023246
 protein coding gene Chr7:69446096-69567100 (+)
DBA/2J ENSMUSG00185045863
 protein coding gene Chr7:73768857-73889863 (+)
FVB/NJ ENSMUSG00205019564
 protein coding gene Chr7:69328412-69449745 (+)
JF1/MsJ ENSUMUG00000015896
 protein coding gene Chr7:78437466-78559248 (+)
LP/J ENSMUSG00230010806
 protein coding gene Chr7:79858154-79979138 (+)
NOD/ShiLtJ ENSMUSG00190018835
 protein coding gene Chr7:69585679-69706980 (+)
NZO/HlLtJ ENSMUSG00225041374
 protein coding gene Chr7:78105349-78226871 (+)
PWK/PhJ ENSLUMG00010017478
 protein coding gene Chr7:68032611-68154417 (+)
SPRET/EiJ ENSMSPG00010021165
 protein coding gene Chr7:68423600-68548344 (+)
WSB/EiJ ENSIUOG00005019299
 protein coding gene Chr7:69932252-70053224 (+)



Homology
more
  • Human Ortholog
    PDE8A, phosphodiesterase 8A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDE8A, phosphodiesterase 8A
  • Synonyms
    HsT19550
  • Links
    NCBI Gene ID: 5151
    UniProt: O60658

  • Chr Location
    15q25.3; chr15:84980440-85139145 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted disruption of this gene results in a 4-fold increase in basal release of testosterone in isolated Leydig cells as well as a significant increase in the sensitivity to luteinizing hormone, measured as testosterone released into the media.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    812
  • Tissues
    154
  • cDNA Data
    46
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025584 Ensembl Gene Model | MGI Sequence Detail 120938 C57BL/6J ±  kb
    transcript ENSMUST00000026672 Ensembl | MGI Sequence Detail 3802 Not Applicable  
    polypeptide ENSMUSP00000026672 Ensembl | MGI Sequence Detail 823 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 51
      cDNA 47
      Primer pair 3
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2141996
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 7
      Gene Ontology 10
      Phenotypes 26
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:366290 Qasim H, et al., AKAP12 Upregulation Associates With PDE8A to Accelerate Cardiac Dysfunction. Circ Res. 2024 Apr 12;134(8):1006-1022
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory