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Utf1 Gene Detail
Summary
  • Symbol
    Utf1
  • Name
    undifferentiated embryonic cell transcription factor 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1276125
    NCBI Gene: 22286
  • Alliance
    genome feature page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:139523769-139525025 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 84.91 cM, cytoband F5
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    133 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1276125
 protein coding gene Chr7:139523702-139525025 (+)
129S1/SvImJ ENSMUSG00200042398
 protein coding gene Chr7:126088467-126089790 (+)
A/J ENSMUSG00195031745
 protein coding gene Chr7:130570821-130572144 (+)
AKR/J ENSMUSG00220034469
 protein coding gene Chr7:124048020-124049343 (+)
BALB/cJ ENSMUSG00180033933
 protein coding gene Chr7:127263075-127264398 (+)
C3H/HeJ ENSMUSG00175031556
 protein coding gene Chr7:127991358-127992681 (+)
C57BL/6NJ ENSMUSG00215042053
 protein coding gene Chr7:127257728-127259051 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030622
 protein coding gene Chr7:142024532-142025852 (+)
CAST/EiJ ENSTCUG00005050172
 protein coding gene Chr7:130555074-130556397 (+)
CBA/J ENSMUSG00210026686
 protein coding gene Chr7:127723474-127724797 (+)
DBA/2J ENSMUSG00185015646
 protein coding gene Chr7:132027782-132029105 (+)
FVB/NJ ENSMUSG00205036990
 protein coding gene Chr7:127714570-127715893 (+)
JF1/MsJ ENSUMUG00000044859
 protein coding gene Chr7:137110583-137111906 (+)
LP/J ENSMUSG00230037430
 protein coding gene Chr7:138191470-138192793 (+)
NOD/ShiLtJ ENSMUSG00190023163
 protein coding gene Chr7:127856831-127858154 (+)
NZO/HlLtJ ENSMUSG00225051005
 protein coding gene Chr7:136400570-136401893 (+)
PWK/PhJ ENSLUMG00010042717
 protein coding gene Chr7:126258003-126259326 (+)
SPRET/EiJ ENSMSPG00010032952
 protein coding gene Chr7:127615555-127616878 (+)
WSB/EiJ ENSIUOG00005030864
 protein coding gene Chr7:128544306-128545629 (+)



Homology
more
  • Human Ortholog
    UTF1, undifferentiated embryonic cell transcription factor 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UTF1, undifferentiated embryonic cell transcription factor 1
  • Links
    NCBI Gene ID: 8433
    UniProt: Q5T230

  • Chr Location
    10q26.3; chr10:133230217-133231558 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 2 genetic backgrounds
    6 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit growth retardation and background sensitive neo- and postnatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    699
  • Tissues
    47
  • cDNA Data
    11
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22286 NCBI Gene Model | MGI Sequence Detail 1257 C57BL/6J ±  kb
    transcript NM_009482 RefSeq | MGI Sequence Detail 1160 C57BL/6  
    polypeptide Q6J1H4 UniProt | EBI | MGI Sequence Detail 339 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000017200 undifferentiated embryonic cell transcription factor 1
      (term hierarchy)
    • InterPro Domains
      IPR044822 Myb/SANT-like DNA-binding domain 4
    • GlyGen
      Q6J1H4 3 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 1
      cDNA 11
      Primer pair 2
      Other 2
      Antibodies 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2141991
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 16
      Gene Ontology 6
      Phenotypes 14
    • Earliest
      J:47012 Okuda A, et al., UTF1, a novel transcriptional coactivator expressed in pluripotent embryonic stem cells and extra-embryonic cells. EMBO J. 1998 Apr 1;17(7):2019-32
    • Latest
      J:373021 Wong FCK, et al., NANOG is repurposed after implantation to repress Sox2 and begin pluripotency extinction. EMBO J. 2025 Oct;44(19):5337-5374
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory