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Ucn Gene Detail
Summary
  • Symbol
    Ucn
  • Name
    urocortin
  • Synonyms
    Ucn1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1276123
    NCBI Gene: 22226
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:31295407-31296173 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 17.11 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    68 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1276123
 protein coding gene Chr5:31295333-31296239 (-)
129S1/SvImJ ENSMUSG00200014023
 protein coding gene Chr5:26795162-26795928 (-)
A/J ENSMUSG00195047016
 protein coding gene Chr5:26242243-26243009 (-)
AKR/J ENSMUSG00220007358
 protein coding gene Chr5:26256366-26257132 (-)
BALB/cJ ENSMUSG00180034092
 protein coding gene Chr5:26046810-26047576 (-)
C3H/HeJ ENSMUSG00175037905
 protein coding gene Chr5:28021126-28021892 (-)
C57BL/6NJ ENSMUSG00215038963
 protein coding gene Chr5:26758494-26759260 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027079
 protein coding gene Chr5:25631308-25632074 (-)
CAST/EiJ ENSTCUG00005018809
 protein coding gene Chr5:26220255-26221021 (-)
CBA/J ENSMUSG00210037589
 protein coding gene Chr5:26994291-26995057 (-)
DBA/2J ENSMUSG00185034591
 protein coding gene Chr5:28849748-28850514 (-)
FVB/NJ ENSMUSG00205037942
 protein coding gene Chr5:25745721-25746487 (-)
JF1/MsJ ENSUMUG00000049661
 protein coding gene Chr5:33391966-33392732 (-)
LP/J ENSMUSG00230043943
 protein coding gene Chr5:33465588-33466354 (-)
NOD/ShiLtJ ENSMUSG00190012526
 protein coding gene Chr5:26046965-26047731 (-)
NZO/HlLtJ ENSMUSG00225017925
 protein coding gene Chr5:38674273-38675039 (-)
PWK/PhJ ENSLUMG00010041068
 protein coding gene Chr5:26138816-26139582 (-)
SPRET/EiJ ENSMSPG00010036256
 protein coding gene Chr5:27304105-27304871 (-)
WSB/EiJ ENSIUOG00005034874
 protein coding gene Chr5:28938163-28938929 (-)



Homology
more
  • Human Ortholog
    UCN, urocortin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UCN, urocortin
  • Synonyms
    UCN1, UI, UROC
  • Links
    NCBI Gene ID: 7349
    UniProt: P55089

  • Chr Location
    2p23.3; chr2:27307400-27308445 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 3 alleles in 3 genetic backgrounds
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutant mice exhibit impaired hearing and reduced acoustic startle response associated with a reduction in outer hair cell length. In addition, some mutant mice exhibit elevated anxiety-like behaviors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    117
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    604
  • Tissues
    5
  • cDNA Data
    5
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038676 Ensembl Gene Model | MGI Sequence Detail 767 C57BL/6J ±  kb
    transcript ENSMUST00000043475 Ensembl | MGI Sequence Detail 504 Not Applicable  
    polypeptide ENSMUSP00000035321 Ensembl | MGI Sequence Detail 122 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      Genomic 2
      cDNA 5
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 10
      Phenotypes 32
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:386745 Prokay AP, et al., Age-dependent alterations of TRPA1 and urocortin 1 signaling in the Edinger-Westphal nucleus in a mouse model of Alzheimer's disease. Sci Rep. 2026 Mar 24;16(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory