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Pde7a Gene Detail
Summary
  • Symbol
    Pde7a
  • Name
    phosphodiesterase 7A
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202402
    NCBI Gene: 18583
  • Alliance
    genome feature page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:19277272-19365486 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 5.36 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2483 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202402
 protein coding gene Chr3:19277272-19365486 (-)
129S1/SvImJ ENSMUSG00200018225
 protein coding gene Chr3:16034849-16123077 (-)
A/J ENSMUSG00195015536
 protein coding gene Chr3:16112463-16200742 (-)
AKR/J ENSMUSG00220008926
 protein coding gene Chr3:16064484-16152709 (-)
BALB/cJ ENSMUSG00180000947
 protein coding gene Chr3:16135493-16226104 (-)
C3H/HeJ ENSMUSG00175003096
 protein coding gene Chr3:16132499-16220773 (-)
C57BL/6NJ ENSMUSG00215001196
 protein coding gene Chr3:16337767-16425982 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024870
 protein coding gene Chr3:14440217-14530350 (-)
CAST/EiJ ENSTCUG00005023553
 protein coding gene Chr3:16047418-16138181 (-)
CBA/J ENSMUSG00210001429
 protein coding gene Chr3:16107784-16196051 (-)
DBA/2J ENSMUSG00185000630
 protein coding gene Chr3:16316356-16407504 (-)
FVB/NJ ENSMUSG00205002404
 protein coding gene Chr3:15620444-15707758 (-)
JF1/MsJ ENSUMUG00000016338
 protein coding gene Chr3:15894147-15982501 (-)
LP/J ENSMUSG00230003823
 protein coding gene Chr3:18222952-18311168 (-)
NOD/ShiLtJ ENSMUSG00190001653
 protein coding gene Chr3:16472556-16563188 (-)
NZO/HlLtJ ENSMUSG00225007191
 protein coding gene Chr3:20867985-20958897 (-)
PWK/PhJ ENSLUMG00010003105
 protein coding gene Chr3:15926707-16014938 (-)
SPRET/EiJ ENSMSPG00010001826
 protein coding gene Chr3:16023269-16107045 (-)
WSB/EiJ ENSIUOG00005001225
 protein coding gene Chr3:16355970-16446951 (-)



Homology
more
  • Human Ortholog
    PDE7A, phosphodiesterase 7A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDE7A, phosphodiesterase 7A
  • Synonyms
    HCP1, PDE7
  • Links
    NCBI Gene ID: 5150
    UniProt: Q13946

  • Chr Location
    8q13.1; chr8:65714334-65842529 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this locus does not impair T cell function but affects the humoral immune response.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    16
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    720
  • Tissues
    108
  • cDNA Data
    16
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18583 NCBI Gene Model | MGI Sequence Detail 88215 C57BL/6J ±  kb
transcript NM_001122759 RefSeq | MGI Sequence Detail 6343 C57BL/6  
polypeptide P70453 UniProt | EBI | MGI Sequence Detail 456 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000012484 high affinity 3',5'-cyclic-AMP phosphodiesterase 7A
    (term hierarchy)
  • EC
    3.1.4.-, 3.1.4.53
  • InterPro Domains
    IPR023088 3'5'-cyclic nucleotide phosphodiesterase
    IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
    IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily
    IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
    IPR003607 HD/PDEase domain
Molecular
Reagents
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  • All nucleic 20
    cDNA 16
    Primer pair 4

    Microarray probesets 9
Other
Accession IDs
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MGI:2139861, MGI:2139950
References
more
  • Summaries
    All 51
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 12
    Phenotypes 12
  • Earliest
    J:49823 Bloom TJ, et al., Identification and tissue-specific expression of PDE7 phosphodiesterase splice variants. Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):14188-92
  • Latest
    J:373370 Liu Z, et al., Neuronal lack of PDE7a disrupted working memory, spatial learning, and memory but facilitated cued fear memory in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2023 Jan 10;120:110655
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory