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Cblif Gene Detail
Summary
  • Symbol
    Cblif
  • Name
    cobalamin binding intrinsic factor
  • Synonyms
    Gif
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202394
    NCBI Gene: 14603
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:11724918-11740811 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 8.51 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    548 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202394
 protein coding gene Chr19:11724907-11740811 (+)
129S1/SvImJ ENSMUSG00200044413
 protein coding gene Chr19:8412545-8428434 (+)
A/J ENSMUSG00195046937
 protein coding gene Chr19:8615256-8631146 (+)
AKR/J ENSMUSG00220040609
 protein coding gene Chr19:8520896-8536777 (+)
BALB/cJ ENSMUSG00180036195
 protein coding gene Chr19:8979823-8995706 (+)
C3H/HeJ ENSMUSG00175010080
 protein coding gene Chr19:8251465-8267346 (+)
C57BL/6NJ ENSMUSG00215034594
 protein coding gene Chr19:8323076-8338966 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022732
 protein coding gene Chr19:9210230-9226820 (+)
CAST/EiJ ENSTCUG00005030373
 protein coding gene Chr19:8116382-8132282 (+)
CBA/J ENSMUSG00210038328
 protein coding gene Chr19:8449989-8465868 (+)
DBA/2J ENSMUSG00185050038
 protein coding gene Chr19:8859992-8875873 (+)
FVB/NJ ENSMUSG00205050563
 protein coding gene Chr19:8319035-8334915 (+)
JF1/MsJ ENSUMUG00000055237
 protein coding gene Chr19:8977533-8993573 (+)
LP/J ENSMUSG00230053540
 protein coding gene Chr19:9780333-9796226 (+)
NOD/ShiLtJ ENSMUSG00190049809
 protein coding gene Chr19:8077898-8093775 (+)
NZO/HlLtJ ENSMUSG00225043586
 protein coding gene Chr19:13489254-13505143 (+)
PWK/PhJ ENSLUMG00010007844
 protein coding gene Chr19:8382258-8398231 (+)
SPRET/EiJ ENSMSPG00010048616
 protein coding gene Chr19:8197588-8213633 (+)
WSB/EiJ ENSIUOG00005048676
 protein coding gene Chr19:7941844-7957737 (+)



Homology
more
  • Human Ortholog
    CBLIF, cobalamin binding intrinsic factor
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CBLIF, cobalamin binding intrinsic factor
  • Synonyms
    GIF, IF, IFMH, INF, TCN3
  • Links
    NCBI Gene ID: 2694
    UniProt: P27352

  • Chr Location
    11q12.1; chr11:59829273-59845499 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human CBLIF associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit vitamin B12-sensitive susceptibility to bacterial infection and reduced body weight and altered blood chemistry that can be compensated by maternal effect.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    626
  • Tissues
    19
  • cDNA Data
    6
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024682 Ensembl Gene Model | MGI Sequence Detail 15894 C57BL/6J ±  kb
    transcript ENSMUST00000025585 Ensembl | MGI Sequence Detail 1537 Not Applicable  
    polypeptide ENSMUSP00000025585 Ensembl | MGI Sequence Detail 417 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      Genomic 2
      cDNA 6
      Primer pair 4
      Antibodies 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2147670, MGI:6277135
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 18
      Gene Ontology 8
      Phenotypes 14
    • Earliest
      J:319880 Coffey JW, et al., Studies on the Interaction of Vitamin B12: Intrinsic Factor and Receptors. Arch Biochem Biophys. 1965 Apr;110:117-123
    • Latest
      J:377277 Halstead AM, et al., A New Model of Gastric Pre-neoplasia Induced by Aberrant ADAR1-mediated Double-stranded RNA Signaling. Cell Mol Gastroenterol Hepatol. 2025 Nov 4;20(3):101673
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory