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Cdk2ap1 Gene Detail
Summary
  • Symbol
    Cdk2ap1
  • Name
    cyclin dependent kinase 2 associated protein 1
  • Synonyms
    Doc1, DORC1, p12, ST19
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202069
    NCBI Gene: 13445
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
  • Regulated by
    Rr130 (1 regulatory region)
Location &
Maps
more
  • Sequence Map
    Chr5:124483502-124492691 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 63.53 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    232 from dbSNP Build 142
  • Strain Annotations
    29
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202069
 protein coding gene Chr5:124483480-124501145 (-)
129S1/SvImJ ENSMUSG00200040211
 protein coding gene Chr11:45771732-45773041 (-)
129S1/SvImJ ENSMUSG00200028232
 protein coding gene Chr5:118206216-118223885 (-)
A/J ENSMUSG00195033812
 protein coding gene Chr11:45716163-45717472 (-)
A/J ENSMUSG00195012191
 protein coding gene Chr5:117727779-117745450 (-)
AKR/J ENSMUSG00220033507
 protein coding gene Chr11:45921628-45922937 (-)
AKR/J ENSMUSG00220044436
 protein coding gene Chr5:117237736-117255389 (-)
BALB/cJ ENSMUSG00180032119
 protein coding gene Chr11:45705828-45707137 (-)
BALB/cJ ENSMUSG00180036145
 protein coding gene Chr5:117842699-117860373 (-)
BALB/cJ ENSMUSG00180023631
 protein coding gene Chr5:38729817-38731126 (-)
C3H/HeJ ENSMUSG00175030193
 protein coding gene Chr11:45747919-45749228 (-)
C3H/HeJ ENSMUSG00175024612
 protein coding gene Chr5:119843956-119861609 (-)
C57BL/6NJ ENSMUSG00215015537
 protein coding gene Chr5:117892600-117910270 (-)
C57BL/6NJ ENSMUSG00215024834
 protein coding gene Chr11:45674781-45676090 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027748
 protein coding gene Chr5:117345325-117354415 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210009833
 protein coding gene Chr5:118594921-118612568 (-)
CBA/J ENSMUSG00210027013
 protein coding gene Chr11:45603867-45605176 (-)
DBA/2J ENSMUSG00185006661
 protein coding gene Chr5:121645978-121663629 (-)
DBA/2J ENSMUSG00185026346
 protein coding gene Chr11:45786160-45787469 (-)
DBA/2J ENSMUSG00185001392
 protein coding gene Chr5:41538169-41539472 (-)
FVB/NJ ENSMUSG00205041240
 protein coding gene Chr5:117520473-117538146 (-)
FVB/NJ ENSMUSG00205016997
 protein coding gene Chr5:38448003-38449306 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230045106
 protein coding gene Chr5:125728115-125745782 (-)
LP/J ENSMUSG00230028688
 protein coding gene Chr11:46925384-46926693 (-)
LP/J ENSMUSG00230037039
 protein coding gene Chr13:105940584-105941786 (+)
NOD/ShiLtJ ENSMUSG00190029099
 protein coding gene Chr11:45858166-45859475 (-)
NOD/ShiLtJ ENSMUSG00190039794
 protein coding gene Chr5:117520349-117538000 (-)
NZO/HlLtJ ENSMUSG00225033018
 protein coding gene Chr13:98465777-98466968 (+)
NZO/HlLtJ ENSMUSG00225013862
 protein coding gene Chr5:133425383-133443046 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    CDK2AP1, cyclin dependent kinase 2 associated protein 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDK2AP1, cyclin dependent kinase 2 associated protein 1
  • Synonyms
    doc-1, DOC1, DORC1, p12DOC-1, ST19
  • Links
    NCBI Gene ID: 8099
    UniProt: O14519

  • Chr Location
    12q24.31; chr12:123250112-123272334 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    1 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mic homozygous for a knock-out allele die between E3.5 and E5.5 with rare survivors exhibiting craniofacial defect.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    609
  • Tissues
    8
  • cDNA Data
    124
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13445 NCBI Gene Model | MGI Sequence Detail 9190 C57BL/6J ±  kb
    transcript NM_013812 RefSeq | MGI Sequence Detail 1283 Not Specified  
    polypeptide O35207 UniProt | EBI | MGI Sequence Detail 114 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 127
      Genomic 1
      cDNA 124
      Primer pair 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 6
      Gene Ontology 5
      Phenotypes 15
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:317152 Dehghan Z, et al., MicroRNA-21 is involved in oocyte maturation, blastocyst formation, and pre-implantation embryo development. Dev Biol. 2021 Dec;480:69-77
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory