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Birc2 Gene Detail
Summary
  • Symbol
    Birc2
  • Name
    baculoviral IAP repeat-containing 2
  • Synonyms
    Api1, C330006D17Rik, cIAP-1, cIAP1, HIAP1, IAP1, mcIAP1, MIAP1, MIHB
  • Feature Type
    protein coding gene
  • IDs
    MGI:1197009
    NCBI Gene: 11797
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:7818228-7837065 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 2.46 cM, cytoband A1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    539 from dbSNP Build 142
  • Strain Annotations
    30
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1197009
 protein coding gene Chr9:7818227-7837123 (-)
129S1/SvImJ ENSMUSG00200022522
 protein coding gene Chr9:4720820-4721197 (-)
129S1/SvImJ ENSMUSG00200022511
 protein coding gene Chr9:4702348-4719512 (-)
A/J ENSMUSG00195018848
 protein coding gene Chr9:4599600-4599977 (-)
A/J ENSMUSG00195018806
 protein coding gene Chr9:4581138-4598292 (-)
AKR/J ENSMUSG00220018575
 protein coding gene Chr9:4750155-4767451 (-)
BALB/cJ ENSMUSG00180011413
 protein coding gene Chr9:4737503-4737880 (-)
BALB/cJ ENSMUSG00180011405
 protein coding gene Chr9:4719041-4736195 (-)
C3H/HeJ ENSMUSG00175023624
 protein coding gene Chr9:4638081-4655235 (-)
C3H/HeJ ENSMUSG00175023648
 protein coding gene Chr9:4656543-4656920 (-)
C57BL/6NJ ENSMUSG00215006319
 protein coding gene Chr9:4673294-4673671 (-)
C57BL/6NJ ENSMUSG00215006285
 protein coding gene Chr9:4654831-4671986 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031761
 protein coding gene Chr9:4025778-4042530 (-)
CAST/EiJ ENSTCUG00005007125
 protein coding gene Chr9:4714450-4731117 (-)
CBA/J ENSMUSG00210010488
 protein coding gene Chr9:4669679-4686835 (-)
CBA/J ENSMUSG00210010497
 protein coding gene Chr9:4688143-4688520 (-)
DBA/2J ENSMUSG00185004862
 protein coding gene Chr9:4787017-4804171 (-)
DBA/2J ENSMUSG00185004866
 protein coding gene Chr9:4805479-4805856 (-)
FVB/NJ ENSMUSG00205006978
 protein coding gene Chr9:4766892-4784048 (-)
FVB/NJ ENSMUSG00205006985
 protein coding gene Chr9:4785356-4785733 (-)
JF1/MsJ ENSUMUG00000006055
 protein coding gene Chr9:4823685-4840454 (-)
LP/J ENSMUSG00230003203
 protein coding gene Chr9:5250036-5267197 (-)
LP/J ENSMUSG00230003260
 protein coding gene Chr9:5268505-5268882 (-)
NOD/ShiLtJ ENSMUSG00190021415
 protein coding gene Chr9:4690483-4707637 (-)
NOD/ShiLtJ ENSMUSG00190021445
 protein coding gene Chr9:4708945-4709322 (-)
NZO/HlLtJ ENSMUSG00225016424
 protein coding gene Chr9:5126598-5143752 (-)
NZO/HlLtJ ENSMUSG00225016456
 protein coding gene Chr9:5145060-5145437 (-)
PWK/PhJ ENSLUMG00010006297
 protein coding gene Chr9:4784792-4802982 (-)
SPRET/EiJ ENSMSPG00010005491
 protein coding gene Chr9:4845268-4861347 (-)
WSB/EiJ ENSIUOG00005007472
 protein coding gene Chr9:4587085-4604267 (-)



Homology
more
  • Human Ortholog
    BIRC2, baculoviral IAP repeat containing 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BIRC2, baculoviral IAP repeat containing 2
  • Synonyms
    API1, c-IAP1, cIAP1, Hiap-2, HIAP2, IAP-2, MIHB, RNF48
  • Links
    NCBI Gene ID: 329
    UniProt: Q13490

  • Chr Location
    11q22.2; chr11:102347208-102378680 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human BIRC2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotypes from multigenic genotypes
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice showed a modest reduction in the number of lymphocytes. Mice homozygous for a knock-in allele exhibit increased T cell poliferation and IFNG secretion in response to anti-CD3 stimulation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    100
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    678
  • Tissues
    37
  • cDNA Data
    12
  • Literature Summary
    16
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000057367 Ensembl Gene Model | MGI Sequence Detail 18838 C57BL/6J ±  kb
transcript ENSMUST00000074246 Ensembl | MGI Sequence Detail 3130 Not Applicable  
polypeptide ENSMUSP00000091422 Ensembl | MGI Sequence Detail 612 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    Genomic 1
    cDNA 12
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:1924866, MGI:2143294
References
more
  • Summaries
    All 118
    Developmental Gene Expression 16
    Gene Ontology 17
    Phenotypes 34
  • Earliest
    J:21378 Tebo JM, et al., Murine inhibitory protein-kappa B alpha negatively regulates kappa B-dependent transcription in lipopolysaccharide-stimulated RAW 264.7 macrophages. J Immunol. 1994 Nov 15;153(10):4713-20
  • Latest
    J:365108 Shaikh K, et al., ZFAND6 promotes TRAF2-dependent mitophagy to restrain cGAS-STING signaling. iScience. 2025 Jan 17;28(1):111544
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory