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Psmb5 Gene Detail
Summary
  • Symbol
    Psmb5
  • Name
    proteasome (prosome, macropain) subunit, beta type 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1194513
    NCBI Gene: 19173
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:54851577-54855452 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 27.86 cM, cytoband C2-D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    176 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1194513
 protein coding gene Chr14:54851576-54855479 (-)
129S1/SvImJ ENSMUSG00200040475
 protein coding gene Chr14:43432289-43436206 (-)
A/J ENSMUSG00195028645
 protein coding gene Chr14:43656590-43660507 (-)
AKR/J ENSMUSG00220025535
 protein coding gene Chr14:42984554-42988471 (-)
BALB/cJ ENSMUSG00180046359
 protein coding gene Chr14:43280356-43284273 (-)
C3H/HeJ ENSMUSG00175047685
 protein coding gene Chr14:44962756-44966673 (-)
C57BL/6NJ ENSMUSG00215046650
 protein coding gene Chr14:43174532-43178435 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019262
 protein coding gene Chr14:46041990-46046011 (-)
CAST/EiJ ENSTCUG00005047176
 protein coding gene Chr14:44960296-44964213 (-)
CBA/J ENSMUSG00210043446
 protein coding gene Chr14:43643298-43647215 (-)
DBA/2J ENSMUSG00185050322
 protein coding gene Chr14:48690092-48694014 (-)
FVB/NJ ENSMUSG00205031285
 protein coding gene Chr14:43032703-43036620 (-)
JF1/MsJ ENSUMUG00000020798
 protein coding gene Chr14:59937642-59941547 (-)
LP/J ENSMUSG00230052628
 protein coding gene Chr14:60797717-60802178 (-)
NOD/ShiLtJ ENSMUSG00190035502
 protein coding gene Chr14:43393590-43397507 (-)
NZO/HlLtJ ENSMUSG00225048867
 protein coding gene Chr14:51095854-51100315 (-)
PWK/PhJ ENSLUMG00010046334
 protein coding gene Chr14:42866216-42870133 (-)
SPRET/EiJ ENSMSPG00010038699
 protein coding gene Chr14:46263586-46267505 (-)
WSB/EiJ ENSIUOG00005034376
 protein coding gene Chr14:42858078-42861996 (-)



Homology
more
  • Human Ortholog
    PSMB5, proteasome 20S subunit beta 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PSMB5, proteasome 20S subunit beta 5
  • Synonyms
    LMPX, MB1
  • Links
    NCBI Gene ID: 5693
    UniProt: P28074

  • Chr Location
    14q11.2; chr14:23016543-23035230 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    4
  • Gene trapped
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Psmb5
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
    20 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    605
  • Tissues
    2
  • cDNA Data
    143
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 19173 NCBI Gene Model | MGI Sequence Detail 3876 C57BL/6J ±  kb
transcript NM_011186 RefSeq | MGI Sequence Detail 871 B10.A-H2  
polypeptide O55234 UniProt | EBI | MGI Sequence Detail 264 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 146
    Genomic 1
    cDNA 143
    Primer pair 2
    Antibodies 1

    Microarray probesets 4
References
more
  • Summaries
    All 49
    Developmental Gene Expression 6
    Gene Ontology 11
    Phenotypes 7
  • Earliest
    J:44713 Kohda K, et al., Structural analysis and chromosomal localization of the mouse Psmb5 gene coding for the constitutively expressed beta-type proteasome subunit. Immunogenetics. 1997;47(1):77-87
  • Latest
    J:361728 Wang Y, et al., The DYT6 dystonia causative protein THAP1 is responsible for proteasome activity via PSMB5 transcriptional regulation. Nat Commun. 2025 Feb 14;16(1):1600
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory