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Fpr3 Gene Detail
Summary
  • Symbol
    Fpr3
  • Name
    formyl peptide receptor 3
  • Synonyms
    Fprl1, Fpr-rs1, LXA4-R, Lxa4r
Location &
Maps
more
  • Sequence Map
    Chr17:18190720-18191939 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 10.66 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    132 from dbSNP Build 142
  • Strain Annotations
    20
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1194495
 protein coding gene Chr17:18108114-18191939 (+)
129S1/SvImJ ENSMUSG00200036910
 protein coding gene Chr17:13564420-13647971 (+)
A/J ENSMUSG00195035090
 protein coding gene Chr17:14452080-14535629 (+)
AKR/J ENSMUSG00220024208
 protein coding gene Chr17:14105642-14189709 (+)
BALB/cJ ENSMUSG00180014980
 protein coding gene Chr17:13748878-13832431 (+)
C3H/HeJ ENSMUSG00175038055
 protein coding gene Chr17:13595740-13679796 (+)
C57BL/6NJ ENSMUSG00215041587
 protein coding gene Chr17:13571963-13655819 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021108
 protein coding gene Chr17:13387199-13441566 (+)
CAST/EiJ ENSTCUG00005022334
 protein coding gene Chr17:14055752-14139451 (+)
CBA/J ENSMUSG00210031068
 protein coding gene Chr17:13403402-13487442 (+)
DBA/2J ENSMUSG00185034559
 protein coding gene Chr17:15586304-15669849 (+)
FVB/NJ ENSMUSG00205016867
 protein coding gene Chr17:14061009-14145065 (+)
FVB/NJ ENSMUSG00205011258
 protein coding gene Chr11:89264009-89265216 (+)
JF1/MsJ ENSUMUG00000034796
 protein coding gene Chr17:15200170-15283900 (+)
LP/J ENSMUSG00230023859
 protein coding gene Chr17:16984501-17068044 (+)
NOD/ShiLtJ ENSMUSG00190036452
 protein coding gene Chr17:13788562-13872405 (+)
NZO/HlLtJ ENSMUSG00225047289
 protein coding gene Chr17:18938153-19021696 (+)
PWK/PhJ ENSLUMG00010017814
 protein coding gene Chr17:13746220-13829810 (+)
SPRET/EiJ ENSMSPG00010032745
 protein coding gene Chr17:15156690-15157909 (+)
WSB/EiJ ENSIUOG00005034522
 protein coding gene Chr17:14423374-14506930 (+)



Homology
more
  • Human Ortholog
    FPR2, formyl peptide receptor 2
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FPR2, formyl peptide receptor 2
  • Synonyms
    ALX, ALXR, FMLP-R-II, FMLPX, FPR2A, FPRH1, FPRH2, FPRL1, HM63, LXA4R
  • Links
    NCBI Gene ID: 2358
    UniProt: P25090

  • Chr Location
    19q13.41; chr19:51752026-51770531 (+)  GRCh38
  • Human Ortholog
    FPR3, formyl peptide receptor 3
  • Synonyms
    FML2_HUMAN, FMLP-R-II, FMLPY, FPRH1, FPRH2, FPRL2, RMLP-R-I
  • Links
    NCBI Gene ID: 2359
    UniProt: P25089

  • Chr Location
    19q13.41; chr19:51795137-51826324 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 3 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14294 NCBI Gene Model | MGI Sequence Detail 1220 C57BL/6J ±  kb
    transcript NM_008042 RefSeq | MGI Sequence Detail 1220 Not Specified  
    polypeptide O08790 UniProt | EBI | MGI Sequence Detail 351 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR000826 Formyl peptide receptor-related
      IPR017452 GPCR, rhodopsin-like, 7TM
      IPR000276 G protein-coupled receptor, rhodopsin-like
    • GlyGen
      O08790 2 sites
    Molecular
    Reagents
    less
    • All nucleic 11
      Genomic 8
      cDNA 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1278320
    References
    more
    • Summaries
      All 48
      Gene Ontology 7
      Phenotypes 10
    • Earliest
      J:40139 Takano T, et al., Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors. J Exp Med. 1997 May 5;185(9):1693-704
    • Latest
      J:373019 Chandrasekharan B, et al., Microbiota-dependent Formylated Peptide Receptor (Fpr1/2) Signaling Regulates Enteric Nervous System Development and Gastrointestinal Motility in Mice. Cell Mol Gastroenterol Hepatol. 2025 Sep 2;:101624
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    09/08/2026
    MGI 6.24     		The Jackson Laboratory