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Flot1 Gene Detail
Summary
  • Symbol
    Flot1
  • Name
    flotillin 1
  • Synonyms
    reggie-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100500
    NCBI Gene: 14251
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:36134243-36143674 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.70 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1100500
 protein coding gene Chr17:36134122-36143683 (+)
129S1/SvImJ ENSMUSG00200046554
 protein coding gene Chr17:31759417-31768998 (+)
A/J ENSMUSG00195042773
 protein coding gene Chr17:32821584-32831141 (+)
AKR/J ENSMUSG00220040628
 protein coding gene Chr17:31622792-31632369 (+)
BALB/cJ ENSMUSG00180033029
 protein coding gene Chr17:32191375-32200933 (+)
C3H/HeJ ENSMUSG00175026367
 protein coding gene Chr17:31508632-31518207 (+)
C57BL/6NJ ENSMUSG00215045919
 protein coding gene Chr17:31584674-31594242 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021533
 protein coding gene Chr17:32598731-32608609 (+)
CAST/EiJ ENSTCUG00005049955
 protein coding gene Chr17:32651027-32660573 (+)
CBA/J ENSMUSG00210038335
 protein coding gene Chr17:31330688-31340269 (+)
DBA/2J ENSMUSG00185045979
 protein coding gene Chr17:34210528-34220085 (+)
FVB/NJ ENSMUSG00205034315
 protein coding gene Chr17:31877739-31887297 (+)
JF1/MsJ ENSUMUG00000041592
 protein coding gene Chr17:33167892-33177639 (+)
LP/J ENSMUSG00230054539
 protein coding gene Chr17:35248101-35257678 (+)
NOD/ShiLtJ ENSMUSG00190042548
 protein coding gene Chr17:31496865-31506420 (+)
NZO/HlLtJ ENSMUSG00225050010
 protein coding gene Chr17:37324809-37334386 (+)
PWK/PhJ ENSLUMG00010042578
 protein coding gene Chr17:31131040-31140552 (+)
SPRET/EiJ ENSMSPG00010049479
 protein coding gene Chr17:32346451-32356188 (+)
WSB/EiJ ENSIUOG00005043552
 protein coding gene Chr17:32313950-32323491 (+)



Homology
more
  • Human Ortholog
    FLOT1, flotillin 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FLOT1, flotillin 1
  • Links
    NCBI Gene ID: 10211
    UniProt: O75955

  • Chr Location
    6p21.33; chr6:30727709-30743075 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired neutrophil recruitment. Homozygous double KO with Flot2 increases susceptibility to induced necroptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    114
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    764
  • Tissues
    109
  • cDNA Data
    95
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 14251 NCBI Gene Model | MGI Sequence Detail 9432 C57BL/6J ±  kb
transcript NM_001410127 RefSeq | MGI Sequence Detail 1699 C57BL/6  
polypeptide O08917 UniProt | EBI | MGI Sequence Detail 428 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 98
    cDNA 95
    Primer pair 1
    Other 2
    Antibodies 1

    Microarray probesets 3
References
more
  • Summaries
    All 68
    Developmental Gene Expression 6
    Gene Ontology 20
    Phenotypes 13
  • Earliest
    J:40485 Bickel PE, et al., Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins. J Biol Chem. 1997 May 23;272(21):13793-802
  • Latest
    J:342152 Honda A, et al., Very-long-chain fatty acids are crucial to neuronal polarity by providing sphingolipids to lipid rafts. Cell Rep. 2023 Oct 31;42(10):113195
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory