About   Help   FAQ
P2rx1 Gene Detail
Summary
  • Symbol
    P2rx1
  • Name
    purinergic receptor P2X, ligand-gated ion channel, 1
  • Synonyms
    P2x, P2X1 receptor, Pdcd3, RP-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098235
    NCBI Gene: 18436
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:72889929-72906026 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 45.09 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    166 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098235
 protein coding gene Chr11:72889882-72906026 (+)
129S1/SvImJ ENSMUSG00200048247
 protein coding gene Chr11:69931956-69948050 (+)
A/J ENSMUSG00195038154
 protein coding gene Chr11:69861748-69877871 (+)
AKR/J ENSMUSG00220042116
 protein coding gene Chr11:70107956-70124048 (+)
BALB/cJ ENSMUSG00180039577
 protein coding gene Chr11:70029597-70045686 (+)
C3H/HeJ ENSMUSG00175053873
 protein coding gene Chr11:69976850-69992941 (+)
C57BL/6NJ ENSMUSG00215050442
 protein coding gene Chr11:69660486-69676601 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016682
 protein coding gene Chr11:67711722-67727871 (+)
CAST/EiJ ENSTCUG00005053521
 protein coding gene Chr11:69523989-69540066 (+)
CBA/J ENSMUSG00210050780
 protein coding gene Chr11:69830843-69846933 (+)
DBA/2J ENSMUSG00185056365
 protein coding gene Chr11:70111301-70127365 (+)
FVB/NJ ENSMUSG00205029044
 protein coding gene Chr11:69948147-69964261 (+)
JF1/MsJ ENSUMUG00000049227
 protein coding gene Chr11:70504532-70520602 (+)
LP/J ENSMUSG00230049047
 protein coding gene Chr11:71142962-71159054 (+)
NOD/ShiLtJ ENSMUSG00190054105
 protein coding gene Chr11:70103908-70119999 (+)
NZO/HlLtJ ENSMUSG00225036237
 protein coding gene Chr11:73327198-73343305 (+)
PWK/PhJ ENSLUMG00010035826
 protein coding gene Chr11:69987530-70003581 (+)
SPRET/EiJ ENSMSPG00010048812
 protein coding gene Chr11:70540162-70556283 (+)
WSB/EiJ ENSIUOG00005045933
 protein coding gene Chr11:70059835-70075910 (+)



Homology
more
  • Human Ortholog
    P2RX1, purinergic receptor P2X 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    P2RX1, purinergic receptor P2X 1
  • Synonyms
    P2X1
  • Links
    NCBI Gene ID: 5023
    UniProt: P51575

  • Chr Location
    17p13.2; chr17:3896592-3916500 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit low male fertility due to impaired vas deferens contraction and reduced numbers of ejaculated sperm. Mutants also show mild hypertension and reduced susceptibility to experimental thromboembolism.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    84
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    49
  • cDNA Data
    20
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020787 Ensembl Gene Model | MGI Sequence Detail 16098 C57BL/6J ±  kb
    transcript ENSMUST00000021141 Ensembl | MGI Sequence Detail 2486 Not Applicable  
    polypeptide ENSMUSP00000021141 Ensembl | MGI Sequence Detail 399 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 1
      cDNA 20
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-32146, MGI:105106, MGI:2144121, MGI:2144602
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 7
      Gene Ontology 18
      Phenotypes 26
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory