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Ppef1 Gene Detail
Summary
  • Symbol
    Ppef1
  • Name
    protein phosphatase with EF hand calcium-binding domain 1
  • Synonyms
    Dres10, PPEF 1, PPEF-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1097157
    NCBI Gene: 237178
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:159406090-159518761 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 73.95 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1950 from dbSNP Build 142
  • Strain Annotations
    24
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1097157
 protein coding gene ChrX:159404997-159534286 (-)
129S1/SvImJ ENSMUSGG00200054952
 protein coding gene ChrX:136146393-136196097 (-)
129S1/SvImJ ENSMUSG00200026366
 protein coding gene ChrX:136198112-136224481 (-)
A/J ENSMUSGG00195055265
 protein coding gene ChrX:141271271-141320971 (-)
A/J ENSMUSG00195036553
 protein coding gene ChrX:141322986-141349353 (-)
AKR/J ENSMUSG00220026801
 protein coding gene ChrX:133179048-133205418 (-)
AKR/J ENSMUSGG00220054660
 protein coding gene ChrX:133127339-133177033 (-)
BALB/cJ ENSMUSG00180039430
 protein coding gene ChrX:136626078-136724218 (-)
C3H/HeJ ENSMUSG00175025504
 protein coding gene ChrX:141260701-141287058 (-)
C3H/HeJ ENSMUSGG00175054868
 protein coding gene ChrX:141208991-141258686 (-)
C57BL/6NJ ENSMUSG00215019386
 protein coding gene ChrX:137093026-137119395 (-)
C57BL/6NJ ENSMUSGG00215055484
 protein coding gene ChrX:137041318-137091011 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033539
 protein coding gene ChrX:149035885-149147701 (-)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210054561
 protein coding gene ChrX:138531472-138581167 (-)
CBA/J ENSMUSG00210036701
 protein coding gene ChrX:138583182-138609541 (-)
DBA/2J ENSMUSG00185028615
 protein coding gene ChrX:153529090-153555450 (-)
DBA/2J ENSMUSGG00185057805
 protein coding gene ChrX:153477386-153527075 (-)
FVB/NJ ENSMUSG00205023303
 protein coding gene ChrX:137195816-137222189 (-)
FVB/NJ ENSMUSGG00205054361
 protein coding gene ChrX:137149302-137193801 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230012024
 protein coding gene ChrX:160319004-160345369 (-)
LP/J ENSMUSGG00230055637
 protein coding gene ChrX:160267293-160316989 (-)
NOD/ShiLtJ ENSMUSG00190027963
 protein coding gene ChrX:137617673-137726918 (-)
NZO/HlLtJ ENSMUSGG00225055460
 protein coding gene ChrX:163656439-163706136 (-)
NZO/HlLtJ ENSMUSG00225037643
 protein coding gene ChrX:163708151-163734520 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    PPEF1, protein phosphatase with EF-hand domain 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPEF1, protein phosphatase with EF-hand domain 1
  • Synonyms
    PP7, PPEF, PPP7C, PPP7CA
  • Links
    NCBI Gene ID: 5475
    UniProt: O14829

  • Chr Location
    Xp22.13; chrX:18675067-18827921 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    8 phenotype references
  • All Mutations and Alleles
    5
  • Endonuclease-mediated
    2
  • Spontaneous
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Ppef1
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    4 strains or lines available
Homozygous null female and hemizygous null male mice are viable, fertile and display no overt abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    648
  • Tissues
    25
  • cDNA Data
    9
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000062168 Ensembl Gene Model | MGI Sequence Detail 112672 C57BL/6J ±  kb
transcript ENSMUST00000071204 Ensembl | MGI Sequence Detail 2483 Not Applicable  
polypeptide ENSMUSP00000071191 Ensembl | MGI Sequence Detail 650 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 9
    Other 1

    Microarray probesets 1
References
more
  • Summaries
    All 35
    Developmental Gene Expression 4
    Gene Ontology 9
    Phenotypes 8
  • Earliest
    J:42619 Banfi S, et al., Drosophila-related expressed sequences. Hum Mol Genet. 1997;6(10):1745-53
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory