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Exoc4 Gene Detail
Summary
  • Symbol
    Exoc4
  • Name
    exocyst complex component 4
  • Synonyms
    Sec8, Sec8l1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096376
    NCBI Gene: 20336
  • Alliance
    genome feature page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:33226025-33950914 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 14.59 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    18248 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096376
 protein coding gene Chr6:33226020-33950914 (+)
129S1/SvImJ ENSMUSG00200045659
 protein coding gene Chr6:30284475-30994217 (+)
A/J ENSMUSG00195032265
 protein coding gene Chr6:30250372-30975483 (+)
AKR/J ENSMUSG00220002905
 protein coding gene Chr6:29845285-30576893 (+)
BALB/cJ ENSMUSG00180036021
 protein coding gene Chr6:30381961-31107118 (+)
C3H/HeJ ENSMUSG00175048209
 protein coding gene Chr6:30246911-30971851 (+)
C57BL/6NJ ENSMUSG00215042483
 protein coding gene Chr6:30279762-31004815 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028201
 protein coding gene Chr6:28052950-28755161 (+)
CAST/EiJ ENSTCUG00005024671
 protein coding gene Chr6:29818387-30539158 (+)
CBA/J ENSMUSG00210052052
 protein coding gene Chr6:30280504-31005447 (+)
DBA/2J ENSMUSG00185040592
 protein coding gene Chr6:30360565-31085668 (+)
FVB/NJ ENSMUSG00205048442
 protein coding gene Chr6:30328755-31038479 (+)
JF1/MsJ ENSUMUG00000005465
 protein coding gene Chr6:30051645-30775048 (+)
LP/J ENSMUSG00230038626
 protein coding gene Chr6:31300799-32010744 (+)
NOD/ShiLtJ ENSMUSG00190047690
 protein coding gene Chr6:30129614-30859733 (+)
NZO/HlLtJ ENSMUSG00225009687
 protein coding gene Chr6:33264883-33989881 (+)
PWK/PhJ ENSLUMG00010022702
 protein coding gene Chr6:29812182-30529868 (+)
SPRET/EiJ ENSMSPG00010027812
 protein coding gene Chr6:30242165-30963462 (+)
WSB/EiJ ENSIUOG00005029963
 protein coding gene Chr6:30417728-31145726 (+)



Homology
more
  • Human Ortholog
    EXOC4, exocyst complex component 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EXOC4, exocyst complex component 4
  • Synonyms
    SEC8, SEC8L1, Sec8p
  • Links
    NCBI Gene ID: 60412
    UniProt: Q96A65

  • Chr Location
    7q33; chr7:133253071-134100951 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display embryonic abnormatlities. Gastrulation is not completed and mesoderm formation is abnormal. Death occurs before E10.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    59
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    681
  • Tissues
    22
  • cDNA Data
    17
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20336 NCBI Gene Model | MGI Sequence Detail 724890 C57BL/6J ±  kb
    transcript NM_009148 RefSeq | MGI Sequence Detail 4781 ZRU/MplStud  
    polypeptide O35382 UniProt | EBI | MGI Sequence Detail 975 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • Protein Ontology
      PR:000007251 exocyst complex component 4
      (term hierarchy)
    • InterPro Domains
      IPR039682 Exocyst complex component Sec8/EXOC4
      IPR048630 Exocyst complex component Sec8, middle helical bundle
      IPR007191 Exocyst complex component Sec8, N-terminal
    • GlyGen
      O35382 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 17
      Primer pair 2
      Antibodies 2

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1353571
    References
    more
    • Summaries
      All 77
      Developmental Gene Expression 10
      Gene Ontology 18
      Phenotypes 22
    • Earliest
      J:79478 Friedrich G, et al., Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev. 1991 Sep;5(9):1513-23
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory