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Gp5 Gene Detail
Summary
  • Symbol
    Gp5
  • Name
    glycoprotein 5 platelet
  • Synonyms
    GP V, GPV
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096363
    NCBI Gene: 14729
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:30126503-30129597 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 21.26 cM, cytoband B2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    151 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096363
 protein coding gene Chr16:30126503-30129599 (-)
129S1/SvImJ ENSMUSG00200034832
 protein coding gene Chr16:27142146-27145241 (-)
A/J ENSMUSG00195028683
 protein coding gene Chr16:26691624-26694719 (-)
AKR/J ENSMUSG00220028947
 protein coding gene Chr16:26978382-26981477 (-)
BALB/cJ ENSMUSG00180025300
 protein coding gene Chr16:26912646-26915741 (-)
C3H/HeJ ENSMUSG00175035258
 protein coding gene Chr16:27061158-27064252 (-)
C57BL/6NJ ENSMUSG00215015856
 protein coding gene Chr16:26930618-26933712 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020645
 protein coding gene Chr16:27338887-27341972 (-)
CAST/EiJ ENSTCUG00005034557
 protein coding gene Chr16:27328013-27331119 (-)
CBA/J ENSMUSG00210032219
 protein coding gene Chr16:27103175-27106269 (-)
DBA/2J ENSMUSG00185017848
 protein coding gene Chr16:27018644-27021738 (-)
FVB/NJ ENSMUSG00205020286
 protein coding gene Chr16:27028338-27031433 (-)
JF1/MsJ ENSUMUG00000032780
 protein coding gene Chr16:27179716-27182823 (-)
LP/J ENSMUSG00230030881
 protein coding gene Chr16:29587530-29590624 (-)
NOD/ShiLtJ ENSMUSG00190033496
 protein coding gene Chr16:27206914-27210009 (-)
NZO/HlLtJ ENSMUSG00225037897
 protein coding gene Chr16:32823804-32826899 (-)
PWK/PhJ ENSLUMG00010031758
 protein coding gene Chr16:27024823-27027926 (-)
SPRET/EiJ ENSMSPG00010017073
 protein coding gene Chr16:26998700-27001801 (-)
WSB/EiJ ENSIUOG00005032530
 protein coding gene Chr16:27177194-27180288 (-)



Homology
more
  • Human Ortholog
    GP5, glycoprotein V platelet
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GP5, glycoprotein V platelet
  • Synonyms
    CD42d, GPV
  • Links
    NCBI Gene ID: 2814
    UniProt: P40197

  • Chr Location
    3q29; chr3:194394821-194399266 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for one null allele develop normally with no spontaneous bleeding while their platelets show normal thrombin responsiveness and lack a Bernard-Soulier phenotype. In contrast, homozygotes for a second null allele show a shorter bleeding time and platelet hyperresponsiveness to thrombin.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    614
  • Tissues
    10
  • cDNA Data
    3
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000047953 Ensembl Gene Model | MGI Sequence Detail 3095 C57BL/6J ±  kb
transcript ENSMUST00000061190 Ensembl | MGI Sequence Detail 2197 Not Applicable  
polypeptide ENSMUSP00000051895 Ensembl | MGI Sequence Detail 567 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000001909 platelet glycoprotein V
    (term hierarchy)
  • InterPro Domains
    IPR000483 Cysteine-rich flanking region, C-terminal
    IPR001611 Leucine-rich repeat
    IPR050541 Leucine-rich repeat and transmembrane domain-containing protein
    IPR032675 Leucine-rich repeat domain superfamily
    IPR003591 Leucine-rich repeat, typical subtype
  • GlyGen
    O08742 7 sites, 3 N-linked glycans (3 sites)
Molecular
Reagents
less
  • All nucleic 6
    Genomic 2
    cDNA 3
    Primer pair 1
    Antibodies 1

    Microarray probesets 4
References
more
  • Summaries
    All 41
    Developmental Gene Expression 3
    Gene Ontology 9
    Phenotypes 7
  • Earliest
    J:40027 Ravanat C, et al., Gene cloning of rat and mouse platelet glycoprotein V: identification of megakaryocyte-specific promoters and demonstration of functional thrombin cleavage. Blood. 1997 May 1;89(9):3253-62
  • Latest
    J:385797 Xia M, et al., A machine learning-based megakaryocyte identification system uncovers resident organs, markers, and functional diversity. Dev Cell. 2026 May 11;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory