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Gckr Gene Detail
Summary
  • Symbol
    Gckr
  • Name
    glucokinase regulatory protein
  • Synonyms
    GKRP, MGC:19300
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096345
    NCBI Gene: 231103
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:31454787-31484658 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 17.27 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    938 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096345
 protein coding gene Chr5:31454594-31484658 (+)
129S1/SvImJ ENSMUSG00200011210
 protein coding gene Chr5:26954944-26984797 (+)
A/J ENSMUSG00195047623
 protein coding gene Chr5:26402123-26431979 (+)
AKR/J ENSMUSG00220007554
 protein coding gene Chr5:26416149-26446000 (+)
BALB/cJ ENSMUSG00180035568
 protein coding gene Chr5:26206675-26236547 (+)
C3H/HeJ ENSMUSG00175039273
 protein coding gene Chr5:28180981-28210846 (+)
C57BL/6NJ ENSMUSG00215026611
 protein coding gene Chr5:26917892-26947761 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027092
 protein coding gene Chr5:25978752-26003335 (+)
CAST/EiJ ENSTCUG00005019405
 protein coding gene Chr5:26377073-26406786 (+)
CBA/J ENSMUSG00210040052
 protein coding gene Chr5:27154137-27183996 (+)
DBA/2J ENSMUSG00185032036
 protein coding gene Chr5:29009129-29038996 (+)
FVB/NJ ENSMUSG00205040162
 protein coding gene Chr5:25905586-25935457 (+)
JF1/MsJ ENSUMUG00000050808
 protein coding gene Chr5:33557103-33586788 (+)
LP/J ENSMUSG00230039815
 protein coding gene Chr5:33625356-33655207 (+)
NOD/ShiLtJ ENSMUSG00190013135
 protein coding gene Chr5:26206332-26236198 (+)
NZO/HlLtJ ENSMUSG00225019001
 protein coding gene Chr5:38833867-38863734 (+)
PWK/PhJ ENSLUMG00010042278
 protein coding gene Chr5:26298256-26327898 (+)
SPRET/EiJ ENSMSPG00010037870
 protein coding gene Chr5:27461469-27491195 (+)
WSB/EiJ ENSIUOG00005037773
 protein coding gene Chr5:29097510-29127406 (+)



Homology
more
  • Human Ortholog
    GCKR, glucokinase regulator
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GCKR, glucokinase regulator
  • Synonyms
    FGQTL5, GKRP
  • Links
    NCBI Gene ID: 2646
    UniProt: Q14397

  • Chr Location
    2p23.3; chr2:27496532-27523688 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human GCKR associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 3 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to reduced glucokinase protein levels and activity in the liver and altered glucose homeostasis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    64
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    633
  • Tissues
    5
  • cDNA Data
    15
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000059434 Ensembl Gene Model | MGI Sequence Detail 29872 C57BL/6J ±  kb
    transcript ENSMUST00000201166 Ensembl | MGI Sequence Detail 2272 Not Applicable  
    polypeptide ENSMUSP00000144202 Ensembl | MGI Sequence Detail 623 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000007896 glucokinase regulatory protein
      (term hierarchy)
    • InterPro Domains
      IPR005486 Glucokinase regulatory protein, conserved site
      IPR054017 Glucokinase regulatory protein, second SIS domain
      IPR040190 N-acetylmuramic acid 6-phosphate etherase/glucokinase regulatory protein
      IPR001347 SIS domain
      IPR046348 SIS domain superfamily
    • GlyGen
      Q91X44 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 15
      Primer pair 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 10
      Phenotypes 38
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:357543 Buziau AM, et al., Hepatic glucokinase regulatory protein and carbohydrate response element binding protein attenuation reduce de novo lipogenesis but do not mitigate intrahepatic triglyceride accumulation in Aldob deficiency. Mol Metab. 2024 Sep;87:101984
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory