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Dnase1l1 Gene Detail
Summary
  • Symbol
    Dnase1l1
  • Name
    deoxyribonuclease 1-like 1
  • Synonyms
    2310005K03Rik, Dnase1ll, Dnl1ll, G4.8
  • Feature Type
    protein coding gene
  • IDs
    MGI:109628
    NCBI Gene: 69537
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:73316823-73325939 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 37.94 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    205 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109628
 protein coding gene ChrX:73316823-73325943 (-)
129S1/SvImJ ENSMUSG00200041730
 protein coding gene ChrX:55377504-55386653 (-)
A/J ENSMUSG00195031378
 protein coding gene ChrX:59053097-59062264 (-)
AKR/J ENSMUSG00220044424
 protein coding gene ChrX:54355408-54364580 (-)
BALB/cJ ENSMUSG00180045978
 protein coding gene ChrX:55633837-55643006 (-)
C3H/HeJ ENSMUSG00175028609
 protein coding gene ChrX:59217464-59226638 (-)
C57BL/6NJ ENSMUSG00215039887
 protein coding gene ChrX:55718094-55727216 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033177
 protein coding gene ChrX:69319800-69331959 (-)
CAST/EiJ ENSTCUG00005038969
 protein coding gene ChrX:57130192-57139473 (-)
CBA/J ENSMUSG00210038278
 protein coding gene ChrX:55898135-55907307 (-)
DBA/2J ENSMUSG00185034100
 protein coding gene ChrX:68319874-68329036 (-)
FVB/NJ ENSMUSG00205031107
 protein coding gene ChrX:55199144-55208313 (-)
JF1/MsJ ENSUMUG00000031164
 protein coding gene ChrX:89055604-89064669 (-)
LP/J ENSMUSG00230032992
 protein coding gene ChrX:74899634-74908783 (-)
NOD/ShiLtJ ENSMUSG00190034572
 protein coding gene ChrX:55138095-55147263 (-)
NZO/HlLtJ ENSMUSG00225048162
 protein coding gene ChrX:80104033-80113180 (-)
PWK/PhJ ENSLUMG00010041586
 protein coding gene ChrX:54876990-54886120 (-)
SPRET/EiJ ENSMSPG00010033213
 protein coding gene ChrX:57961608-57970275 (-)
WSB/EiJ ENSIUOG00005047782
 protein coding gene ChrX:55965615-55974787 (-)



Homology
more
  • Human Ortholog
    DNASE1L1, deoxyribonuclease 1 like 1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DNASE1L1, deoxyribonuclease 1 like 1
  • Synonyms
    DNAS1L1, DNASEX, DNL1L, G4.8, XIB
  • Links
    NCBI Gene ID: 1774
    UniProt: P49184

  • Chr Location
    Xq28; chrX:154401236-154412114 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Female mice homozygous for an inactivating mutation of this gene exhibit poor motor coordination on the rotarod even on days 4 and 5 of a 5-day test.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    30
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 69537 NCBI Gene Model | MGI Sequence Detail 9117 C57BL/6J ±  kb
transcript NM_027109 RefSeq | MGI Sequence Detail 1515 ZRU/MplStud  
polypeptide Q9D7J6 UniProt | EBI | MGI Sequence Detail 314 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 37
    Genomic 4
    cDNA 33

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-35852, MGD-MRK-39627, MGI:107385, MGI:1916787, MGI:2147876
References
more
  • Summaries
    All 39
    Gene Ontology 6
    Phenotypes 8
  • Earliest
    J:26634 Rivella S, et al., A comparative transcriptional map of a region of 250 kb on the human and mouse X chromosome between the G6PD and the FLN1 genes. Genomics. 1995 Aug 10;28(3):377-82
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory