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Srgap2 Gene Detail
Summary
  • Symbol
    Srgap2
  • Name
    SLIT-ROBO Rho GTPase activating protein 2
  • Synonyms
    9930124L22Rik, FBP2, Fnbp2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109605
    NCBI Gene: 14270
  • Alliance
    genome feature page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:131212989-131455090 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 56.93 cM, cytoband E4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4061 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109605
 protein coding gene Chr1:131212989-131455269 (-)
129S1/SvImJ ENSMUSG00200008290
 protein coding gene Chr1:128789286-129022777 (-)
A/J ENSMUSG00195038420
 protein coding gene Chr1:127875418-128115796 (-)
AKR/J ENSMUSG00220044769
 protein coding gene Chr1:127721064-127961556 (-)
BALB/cJ ENSMUSG00180031063
 protein coding gene Chr1:128443893-128677389 (-)
C3H/HeJ ENSMUSG00175036558
 protein coding gene Chr1:128120128-128360508 (-)
C57BL/6NJ ENSMUSG00215043699
 protein coding gene Chr1:128135808-128376175 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014571
 protein coding gene Chr1:122868079-123108960 (-)
CAST/EiJ ENSTCUG00005029830
 protein coding gene Chr1:127056879-127292594 (-)
CBA/J ENSMUSG00210027050
 protein coding gene Chr1:128038358-128271942 (-)
DBA/2J ENSMUSG00185027366
 protein coding gene Chr1:132388148-132621646 (-)
FVB/NJ ENSMUSG00205027160
 protein coding gene Chr1:127375108-127608599 (-)
JF1/MsJ ENSUMUG00000029848
 protein coding gene Chr1:131558939-131790551 (-)
LP/J ENSMUSG00230001117
 protein coding gene Chr1:131967458-132200924 (-)
NOD/ShiLtJ ENSMUSG00190031352
 protein coding gene Chr1:128030030-128270373 (-)
NZO/HlLtJ ENSMUSG00225018829
 protein coding gene Chr1:135704282-135937753 (-)
PWK/PhJ ENSLUMG00010027228
 protein coding gene Chr1:127165067-127396400 (-)
SPRET/EiJ ENSMSPG00010040907
 protein coding gene Chr1:129964148-130205821 (-)
WSB/EiJ ENSIUOG00005045556
 protein coding gene Chr1:127783407-128018639 (-)



Homology
more
  • Human Ortholog
    SRGAP2, SLIT-ROBO Rho GTPase activating protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SRGAP2, SLIT-ROBO Rho GTPase activating protein 2
  • Synonyms
    ARHGAP34, FNBP2, SRGAP2A
  • Links
    NCBI Gene ID: 23380
    UniProt: O75044

  • Chr Location
    1q32.1; chr1:206203346-206464436 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a hypomorphic gene trap allele are born at below the expected Mendelian ratio, but are otherwise viable. Layer 5 cortical pyramidal neurons exhibit an increased density of dendritic spines with a decreased spine head width and increased length of spine necks.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    62
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    881
  • Tissues
    174
  • cDNA Data
    158
  • Literature Summary
    12
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026425 Ensembl Gene Model | MGI Sequence Detail 242102 C57BL/6J ±  kb
transcript ENSMUST00000097588 Ensembl | MGI Sequence Detail 8026 Not Applicable  
polypeptide ENSMUSP00000095195 Ensembl | MGI Sequence Detail 1071 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 161
    cDNA 158
    Primer pair 2
    Other 1
    Antibodies 1

    Microarray probesets 8
Other
Accession IDs
less
MGD-MRK-39604, MGI:2138246
References
more
  • Summaries
    All 77
    Developmental Gene Expression 12
    Gene Ontology 14
    Phenotypes 20
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:390350 Diaz-Salazar C, et al., Human-specific SRGAP2 paralogs synchronize neotenic microglial maturation and synaptic development. Neuron. 2026 Jul 22;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory