About   Help   FAQ
Prpf4b Gene Detail
Summary
  • Symbol
    Prpf4b
  • Name
    pre-mRNA processing factor 4B
  • Synonyms
    MGC:5960, Prp4, Prp4k, Prpk
  • Feature Type
    protein coding gene
  • IDs
    MGI:109584
    NCBI Gene: 19134
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:35059285-35090047 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 14.21 cM, cytoband A5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    735 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109584
 protein coding gene Chr13:35058803-35090047 (+)
129S1/SvImJ ENSMUSG00200010476
 protein coding gene Chr13:32255225-32285990 (+)
A/J ENSMUSG00195030656
 protein coding gene Chr13:31340725-31371495 (+)
AKR/J ENSMUSG00220031064
 protein coding gene Chr13:31130003-31160775 (+)
BALB/cJ ENSMUSG00180007985
 protein coding gene Chr13:31644503-31675274 (+)
C3H/HeJ ENSMUSG00175012249
 protein coding gene Chr13:31593720-31624490 (+)
C57BL/6NJ ENSMUSG00215010672
 protein coding gene Chr13:31783893-31814655 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018423
 protein coding gene Chr13:30321685-30348975 (+)
CAST/EiJ ENSTCUG00005033632
 protein coding gene Chr13:31666246-31697157 (+)
CBA/J ENSMUSG00210011180
 protein coding gene Chr13:31606224-31636994 (+)
DBA/2J ENSMUSG00185030971
 protein coding gene Chr13:32425676-32456442 (+)
FVB/NJ ENSMUSG00205029020
 protein coding gene Chr13:31313674-31344438 (+)
JF1/MsJ ENSUMUG00000017872
 protein coding gene Chr13:32011094-32041989 (+)
LP/J ENSMUSG00230013648
 protein coding gene Chr13:41750047-41780817 (+)
NOD/ShiLtJ ENSMUSG00190010795
 protein coding gene Chr13:31835743-31866505 (+)
NZO/HlLtJ ENSMUSG00225034425
 protein coding gene Chr13:35561039-35591809 (+)
PWK/PhJ ENSLUMG00010026785
 protein coding gene Chr13:30842155-30873031 (+)
SPRET/EiJ ENSMSPG00010010030
 protein coding gene Chr13:30744306-30775025 (+)
WSB/EiJ ENSIUOG00005026921
 protein coding gene Chr13:30996465-31027229 (+)



Homology
more
  • Human Ortholog
    PRP4K, pre-mRNA processing factor kinase PRP4K
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRP4K, pre-mRNA processing factor kinase PRP4K
  • Synonyms
    dJ1013A10.1, PR4H, PRP4, Prp4B, PRP4H, PRPF4B
  • Links
    NCBI Gene ID: 8899
    UniProt: Q13523

  • Chr Location
    6p25.2; chr6:4021266-4064983 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    1 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show failure of blastocyst formation, failure of blastocyst to hatch from the zona pellucida, increased cell death, and complete embryonic lethality before implantation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    614
  • Tissues
    16
  • cDNA Data
    20
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021413 Ensembl Gene Model | MGI Sequence Detail 30763 C57BL/6J ±  kb
transcript ENSMUST00000077853 Ensembl | MGI Sequence Detail 7844 Not Applicable  
polypeptide ENSMUSP00000077019 Ensembl | MGI Sequence Detail 1007 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 22
    cDNA 21
    Primer pair 1

    Microarray probesets 9
Other
Accession IDs
less
MGD-MRK-39583
References
more
  • Summaries
    All 58
    Developmental Gene Expression 4
    Gene Ontology 12
    Phenotypes 22
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory