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Bnip2 Gene Detail
Summary
  • Symbol
    Bnip2
  • Name
    BCL2/adenovirus E1B interacting protein 2
  • Synonyms
    5730523P12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:109327
    NCBI Gene: 12175
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:69896748-69915599 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 39.15 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    362 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109327
 protein coding gene Chr9:69896660-69918941 (+)
129S1/SvImJ ENSMUSG00200042426
 protein coding gene Chr9:66997124-67010016 (+)
A/J ENSMUSG00195026360
 protein coding gene Chr9:66775803-66788714 (+)
AKR/J ENSMUSG00220034491
 protein coding gene Chr9:66914544-66927441 (+)
BALB/cJ ENSMUSG00180015896
 protein coding gene Chr9:66890173-66903083 (+)
C3H/HeJ ENSMUSG00175012039
 protein coding gene Chr9:66903566-66916477 (+)
C57BL/6NJ ENSMUSG00215026264
 protein coding gene Chr9:66846403-66859300 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032397
 protein coding gene Chr9:67162433-67181138 (+)
CAST/EiJ ENSTCUG00005027352
 protein coding gene Chr9:66720619-66733558 (+)
CBA/J ENSMUSG00210014335
 protein coding gene Chr9:66984301-66997209 (+)
DBA/2J ENSMUSG00185030032
 protein coding gene Chr9:67008017-67020925 (+)
FVB/NJ ENSMUSG00205025817
 protein coding gene Chr9:67282231-67295140 (+)
JF1/MsJ ENSUMUG00000012874
 protein coding gene Chr9:67041925-67054879 (+)
LP/J ENSMUSG00230022968
 protein coding gene Chr9:67192266-67205158 (+)
NOD/ShiLtJ ENSMUSG00190020104
 protein coding gene Chr9:67111289-67124182 (+)
NZO/HlLtJ ENSMUSG00225046043
 protein coding gene Chr9:67313789-67326697 (+)
PWK/PhJ ENSLUMG00010026064
 protein coding gene Chr9:66983871-66996824 (+)
SPRET/EiJ ENSMSPG00010018601
 protein coding gene Chr9:68071840-68090800 (+)
WSB/EiJ ENSIUOG00005023135
 protein coding gene Chr9:66469340-66482236 (+)



Homology
more
  • Human Ortholog
    BNIP2, BCL2 interacting protein 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BNIP2, BCL2 interacting protein 2
  • Synonyms
    BNIP-2, NIP2
  • Links
    NCBI Gene ID: 663
    UniProt: Q12982

  • Chr Location
    15q22.2; chr15:59659146-59689350 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    599
  • Tissues
    1
  • cDNA Data
    113
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000011958 Ensembl Gene Model | MGI Sequence Detail 18852 C57BL/6J ±  kb
    transcript ENSMUST00000117450 Ensembl | MGI Sequence Detail 1465 Not Applicable  
    polypeptide ENSMUSP00000113466 Ensembl | MGI Sequence Detail 348 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000004780 BCL2/adenovirus E1B 19 kDa protein-interacting protein 2
      (term hierarchy)
    • InterPro Domains
      IPR022181 Bcl2-/adenovirus E1B 19kDa-interacting protein 2
      IPR001251 CRAL-TRIO lipid binding domain
      IPR036865 CRAL-TRIO lipid binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 116
      cDNA 115
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-38372, MGI:1923989
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 4
      Gene Ontology 9
      Phenotypes 12
    • Earliest
      J:37511 Boyd JM, et al., Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins [see comments] [published erratum appears in Cell 1994 Dec 16;79(6):following 1120]. Cell. 1994 Oct 21;79(2):341-51
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory