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Tsn Gene Detail
Summary
  • Symbol
    Tsn
  • Name
    translin
  • Synonyms
    2610034C24Rik, TB-RBP
  • Feature Type
    protein coding gene
  • IDs
    MGI:109263
    NCBI Gene: 22099
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:118226244-118239463 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 52.14 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    272 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109263
 protein coding gene Chr1:118222508-118239469 (-)
129S1/SvImJ ENSMUSG00200001307
 protein coding gene Chr1:115692866-115709507 (-)
A/J ENSMUSG00195004280
 protein coding gene Chr1:114935179-114951813 (-)
AKR/J ENSMUSG00220024249
 protein coding gene Chr1:114750636-114767278 (-)
BALB/cJ ENSMUSG00180011879
 protein coding gene Chr1:115342526-115359167 (-)
C3H/HeJ ENSMUSG00175018648
 protein coding gene Chr1:115166246-115182879 (-)
C57BL/6NJ ENSMUSG00215010694
 protein coding gene Chr1:115129015-115145651 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014506
 protein coding gene Chr1:110349956-110361782 (-)
CAST/EiJ ENSTCUG00005006209
 protein coding gene Chr1:114077027-114093680 (-)
CBA/J ENSMUSG00210001149
 protein coding gene Chr1:114995870-115012503 (-)
DBA/2J ENSMUSG00185013475
 protein coding gene Chr1:119443745-119460377 (-)
FVB/NJ ENSMUSG00205010713
 protein coding gene Chr1:114493229-114509869 (-)
JF1/MsJ ENSUMUG00000016943
 protein coding gene Chr1:118537228-118554053 (-)
LP/J ENSMUSG00230007198
 protein coding gene Chr1:118870825-118887466 (-)
NOD/ShiLtJ ENSMUSG00190006088
 protein coding gene Chr1:114973996-114990629 (-)
NZO/HlLtJ ENSMUSG00225002287
 protein coding gene Chr1:122662852-122679485 (-)
PWK/PhJ ENSLUMG00010014184
 protein coding gene Chr1:114129335-114146169 (-)
SPRET/EiJ ENSMSPG00010015883
 protein coding gene Chr1:116773242-116783448 (-)
WSB/EiJ ENSIUOG00005002811
 protein coding gene Chr1:114843505-114860145 (-)



Homology
more
  • Human Ortholog
    TSN, translin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TSN, translin
  • Synonyms
    BCLF-1, C3PO, RCHF1, REHF-1, TBRBP, TRSLN
  • Links
    NCBI Gene ID: 7247
    UniProt: Q15631

  • Chr Location
    2q14.3; chr2:121737103-121767853 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 2 alleles in 2 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Inactivation of this gene results in reduced female fertility, growth defects, and abnormalities related to activity and dexterity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22099 NCBI Gene Model | MGI Sequence Detail 13220 C57BL/6J ±  kb
    transcript NM_011650 RefSeq | MGI Sequence Detail 3090 C57BL/6  
    polypeptide Q62348 UniProt | EBI | MGI Sequence Detail 228 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 2
      cDNA 14

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-38308, MGI:1916495, MGI:2138483
    References
    more
    • Summaries
      All 71
      Gene Ontology 12
      Phenotypes 24
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:387928 Liu Y, et al., Conditional Deletion of Translin/Trax in Dopaminergic Neurons Reveals No Impact on Psychostimulant Behaviors or Adiposity. Biomolecules. 2025 Jul 17;15(7)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory