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Isl2 Gene Detail
Summary
  • Symbol
    Isl2
  • Name
    insulin related protein 2 (islet 2)
  • Synonyms
    3110001N10Rik, islet 2, islet-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109156
    NCBI Gene: 104360
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
  • Regulated by
    Rr518 (1 regulatory region)
Location &
Maps
more
  • Sequence Map
    Chr9:55445956-55453464 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 30.13 cM, cytoband C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    197 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109156
 protein coding gene Chr9:55445956-55454951 (+)
129S1/SvImJ ENSMUSG00200033154
 protein coding gene Chr9:52572951-52580462 (+)
A/J ENSMUSG00195037599
 protein coding gene Chr9:52271861-52279373 (+)
AKR/J ENSMUSG00220025065
 protein coding gene Chr9:52404752-52412263 (+)
BALB/cJ ENSMUSG00180016744
 protein coding gene Chr9:52385002-52392510 (+)
C3H/HeJ ENSMUSG00175020436
 protein coding gene Chr9:52396985-52404496 (+)
C57BL/6NJ ENSMUSG00215027156
 protein coding gene Chr9:52370097-52377605 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032247
 protein coding gene Chr9:52282725-52290279 (+)
CAST/EiJ ENSTCUG00005018353
 protein coding gene Chr9:52301344-52308895 (+)
CBA/J ENSMUSG00210031215
 protein coding gene Chr9:52489540-52497049 (+)
DBA/2J ENSMUSG00185037045
 protein coding gene Chr9:52528918-52536428 (+)
FVB/NJ ENSMUSG00205037504
 protein coding gene Chr9:52811303-52818814 (+)
JF1/MsJ ENSUMUG00000043892
 protein coding gene Chr9:52536350-52543893 (+)
LP/J ENSMUSG00230032777
 protein coding gene Chr9:52772902-52780413 (+)
NOD/ShiLtJ ENSMUSG00190029445
 protein coding gene Chr9:52589124-52596635 (+)
NZO/HlLtJ ENSMUSG00225027998
 protein coding gene Chr9:52796809-52804320 (+)
PWK/PhJ ENSLUMG00010036716
 protein coding gene Chr9:52512448-52519991 (+)
SPRET/EiJ ENSMSPG00010022225
 protein coding gene Chr9:53502102-53509640 (+)
WSB/EiJ ENSIUOG00005036564
 protein coding gene Chr9:51995961-52003474 (+)



Homology
more
  • Human Ortholog
    ISL2, ISL LIM homeobox 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ISL2, ISL LIM homeobox 2
  • Links
    NCBI Gene ID: 64843
    UniProt: Q96A47

  • Chr Location
    15q24.3; chr15:76336773-76342475 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 3 alleles in 3 genetic backgrounds
    10 phenotypes from multigenic genotypes
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations of this gene result in neonatal lethality, motor neuron migration defects and impaired visceral motor neuron differentiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1412
  • Tissues
    181
  • cDNA Data
    14
  • Literature Summary
    396
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032318 Ensembl Gene Model | MGI Sequence Detail 7509 C57BL/6J ±  kb
    transcript ENSMUST00000034869 Ensembl | MGI Sequence Detail 1854 Not Applicable  
    polypeptide ENSMUSP00000034869 Ensembl | MGI Sequence Detail 359 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 14
      Primer pair 4
      Other 2
      Antibodies 49

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-38200, MGI:1917602
    References
    more
    • Summaries
      All 478
      Developmental Gene Expression 396
      Gene Ontology 11
      Phenotypes 50
    • Earliest
      J:31131 Pfaff SL, et al., Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation. Cell. 1996 Jan 26;84(2):309-20
    • Latest
      J:382758 Segarra LC, et al., Evidence for chronological diversification of spinal neuron subtypes by a shared sequence of transcription factors. Sci Adv. 2026 Mar 20;12(12):eadz3075
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory