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Cbx3 Gene Detail
Summary
  • Symbol
    Cbx3
  • Name
    chromobox 3
  • Synonyms
    heterochromatin protein 1 gamma, HP1g, M32
  • Feature Type
    protein coding gene
  • IDs
    MGI:108515
    NCBI Gene: 12417
  • Alliance
    genome feature page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:51447596-51460684 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 24.89 cM, cytoband B-C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    374 from dbSNP Build 142
  • Strain Annotations
    33
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108515
 protein coding gene Chr6:51447340-51460684 (+)
129S1/SvImJ ENSMUSG00200018492
 protein coding gene Chr1:56189327-56191085 (+)
129S1/SvImJ ENSMUSG00200005182
 protein coding gene Chr6:48419625-48432971 (+)
129S1/SvImJ ENSMUSG00200009480
 protein coding gene Chr14:62626768-62628506 (-)
A/J ENSMUSG00195006783
 protein coding gene Chr6:48145546-48158892 (+)
A/J ENSMUSG00195003867
 protein coding gene Chr14:62761375-62763110 (-)
A/J ENSMUSG00195025970
 protein coding gene Chr1:55722573-55724311 (+)
AKR/J ENSMUSG00220038525
 protein coding gene Chr1:55812733-55814491 (+)
AKR/J ENSMUSG00220002944
 protein coding gene Chr6:47846774-47860115 (+)
BALB/cJ ENSMUSG00180013943
 protein coding gene Chr1:55970416-55972154 (+)
BALB/cJ ENSMUSG00180020568
 protein coding gene Chr6:48447415-48460758 (+)
BALB/cJ ENSMUSG00180020988
 protein coding gene Chr14:62367827-62369561 (-)
C3H/HeJ ENSMUSG00175000910
 protein coding gene Chr1:56100072-56101810 (+)
C3H/HeJ ENSMUSG00175015595
 protein coding gene Chr6:48213872-48227219 (+)
C57BL/6NJ ENSMUSG00215008919
 protein coding gene Chr6:48400074-48413418 (+)
C57BL/6NJ ENSMUSG00215023306
 protein coding gene Chr1:56031845-56033603 (+)
C57BL/6NJ ENSMUSG00215018393
 protein coding gene Chr14:62343252-62344987 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028378
 protein coding gene Chr6:45965627-45978860 (+)
CAST/EiJ ENSTCUG00005004899
 protein coding gene Chr6:47698901-47712221 (+)
CBA/J ENSMUSG00210018202
 protein coding gene Chr6:48258150-48271496 (+)
DBA/2J ENSMUSG00185012967
 protein coding gene Chr6:48840428-48853774 (+)
FVB/NJ ENSMUSG00205025546
 protein coding gene Chr6:48498554-48511901 (+)
FVB/NJ ENSMUSG00205017226
 protein coding gene Chr1:55745877-55747635 (+)
FVB/NJ ENSMUSG00205022432
 protein coding gene Chr14:62187466-62189198 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230018714
 protein coding gene Chr6:49916933-49930279 (+)
LP/J ENSMUSG00230014279
 protein coding gene Chr14:79976905-79978643 (-)
LP/J ENSMUSG00230024300
 protein coding gene Chr1:56909899-56911637 (+)
NOD/ShiLtJ ENSMUSG00190029932
 protein coding gene Chr6:48178099-48191427 (+)
NOD/ShiLtJ ENSMUSG00190032297
 protein coding gene Chr1:55951550-55953320 (+)
NOD/ShiLtJ ENSMUSG00190010478
 protein coding gene Chr14:62511809-62513674 (-)
NZO/HlLtJ ENSMUSG00225012991
 protein coding gene Chr6:51898210-51911555 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010008149
 protein coding gene Chr6:48537534-48551078 (+)
WSB/EiJ ENSIUOG00005027106
 protein coding gene Chr6:48515748-48529089 (+)



Homology
more
  • Human Ortholog
    CBX3, chromobox 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CBX3, chromobox 3
  • Synonyms
    HECH, HP1-GAMMA, HP1gamma, HP1Hs-gamma
  • Links
    NCBI Gene ID: 11335
    UniProt: Q13185

  • Chr Location
    7p15.2; chr7:26201162-26213607 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 3 alleles in 3 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele are infertile. Mice homozygous for a hypomorphic targeted allele exhibit partial postnatal lethality and male infertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    769
  • Tissues
    157
  • cDNA Data
    14
  • Literature Summary
    26
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12417 NCBI Gene Model | MGI Sequence Detail 13089 C57BL/6J ±  kb
    transcript NM_001355002 RefSeq | MGI Sequence Detail 1938 ZRU/MplStud  
    polypeptide P23198 UniProt | EBI | MGI Sequence Detail 183 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 17
      Primer pair 3
      Antibodies 1

      Microarray probesets 13
    Other
    Accession IDs
    less
    MGD-MRK-37559
    References
    more
    • Summaries
      All 122
      Developmental Gene Expression 26
      Gene Ontology 20
      Phenotypes 22
    • Earliest
      J:32398 Singh PB, et al., A sequence motif found in a Drosophila heterochromatin protein is conserved in animals and plants. Nucleic Acids Res. 1991 Feb 25;19(4):789-94
    • Latest
      J:370951 Newman AG, et al., Glial reactivity and cognitive decline follow chronic heterochromatin loss in neurons. Nat Commun. 2025 Aug 8;16(1):7325
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory