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Pafah1b3 Gene Detail
Summary
  • Symbol
    Pafah1b3
  • Name
    platelet-activating factor acetylhydrolase, isoform 1b, subunit 3
  • Synonyms
    mus[g], PAF-AH alpha1, Pafahg
  • Feature Type
    protein coding gene
  • IDs
    MGI:108414
    NCBI Gene: 18476
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:24994473-24997377 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 13.73 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    110 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108414
 protein coding gene Chr7:24994473-24997411 (-)
129S1/SvImJ ENSMUSG00200040401
 protein coding gene Chr7:14997565-15001239 (-)
A/J ENSMUSG00195052113
 protein coding gene Chr7:17434761-17438437 (-)
AKR/J ENSMUSG00220051433
 protein coding gene Chr7:26952249-26955822 (+)
BALB/cJ ENSMUSG00180052528
 protein coding gene Chr7:15506727-15510403 (-)
C3H/HeJ ENSMUSG00175041883
 protein coding gene Chr7:16550839-16554515 (-)
C57BL/6NJ ENSMUSG00215054594
 protein coding gene Chr7:14910683-14914359 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029363
 protein coding gene Chr7:24562884-24565735 (-)
CAST/EiJ ENSTCUG00005049494
 protein coding gene Chr7:16605246-16608578 (-)
CBA/J ENSMUSG00210052635
 protein coding gene Chr7:15736566-15740242 (-)
DBA/2J ENSMUSG00185054045
 protein coding gene Chr7:18950323-18953999 (-)
FVB/NJ ENSMUSG00205050235
 protein coding gene Chr7:15747167-15750843 (-)
JF1/MsJ ENSUMUG00000017223
 protein coding gene Chr7:23246615-23249737 (-)
LP/J ENSMUSG00230052550
 protein coding gene Chr7:24223722-24227396 (-)
NOD/ShiLtJ ENSMUSG00190041657
 protein coding gene Chr7:15217461-15221135 (-)
NZO/HlLtJ ENSMUSG00225024855
 protein coding gene Chr7:22892323-22895999 (-)
PWK/PhJ ENSLUMG00010045811
 protein coding gene Chr7:15180413-15183528 (-)
SPRET/EiJ ENSMSPG00010039896
 protein coding gene Chr7:14845190-14848289 (-)
WSB/EiJ ENSIUOG00005049331
 protein coding gene Chr7:9712586-9716256 (-)



Homology
more
  • Human Ortholog
    PAFAH1B3, platelet activating factor acetylhydrolase 1b catalytic subunit 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PAFAH1B3, platelet activating factor acetylhydrolase 1b catalytic subunit 3
  • Synonyms
    PAFAHG
  • Links
    NCBI Gene ID: 5050
    UniProt: Q15102

  • Chr Location
    19q13.2; chr19:42297023-42303546 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotypes from multigenic genotypes
    2 images
    12 phenotype references
Homozygous null mice of both sexes are viable and fertile. However, in combination with homozygous disruptions in Pafah1b2, males become infertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    885
  • Tissues
    217
  • cDNA Data
    115
  • Literature Summary
    11
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18476 NCBI Gene Model | MGI Sequence Detail 2905 C57BL/6J ±  kb
transcript NM_001357350 RefSeq | MGI Sequence Detail 1239 C57BL/6  
polypeptide Q61205 UniProt | EBI | MGI Sequence Detail 232 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 118
    cDNA 115
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-37457
References
more
  • Summaries
    All 55
    Developmental Gene Expression 11
    Gene Ontology 11
    Phenotypes 12
  • Earliest
    J:37333 Albrecht U, et al., Platelet-activating factor acetylhydrolase expression and activity suggest a link between neuronal migration and platelet-activating factor. Dev Biol. 1996 Dec 15;180(2):579-93
  • Latest
    J:197131 Lanctot AA, et al., Spatially dependent dynamic MAPK modulation by the nde1-lis1-brap complex patterns Mammalian CNS. Dev Cell. 2013 May 13;25(3):241-55
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory