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Npy5r Gene Detail
Summary
  • Symbol
    Npy5r
  • Name
    neuropeptide Y receptor Y5
  • Synonyms
    Y5R
Location &
Maps
more
  • Sequence Map
    Chr8:67132617-67140746 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 33.15 cM, cytoband B3-C2
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    333 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108082
 protein coding gene Chr8:67132617-67140780 (-)
129S1/SvImJ ENSMUSG00200032212
 protein coding gene Chr8:61974408-61982565 (-)
A/J ENSMUSG00195015254
 protein coding gene Chr8:62375599-62383762 (-)
AKR/J ENSMUSG00220021500
 protein coding gene Chr8:62181805-62189976 (-)
BALB/cJ ENSMUSG00180019155
 protein coding gene Chr8:61950519-61958670 (-)
C3H/HeJ ENSMUSG00175019854
 protein coding gene Chr8:62181617-62189786 (-)
C57BL/6NJ ENSMUSG00215025047
 protein coding gene Chr8:61957836-61965993 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031095
 protein coding gene Chr8:59062987-59070887 (-)
CAST/EiJ ENSTCUG00005039500
 protein coding gene Chr8:61738896-61747124 (-)
CBA/J ENSMUSG00210028468
 protein coding gene Chr8:62060559-62068734 (-)
DBA/2J ENSMUSG00185021874
 protein coding gene Chr8:68113629-68121796 (-)
FVB/NJ ENSMUSG00205039154
 protein coding gene Chr8:61522766-61530943 (-)
JF1/MsJ ENSUMUG00000009280
 protein coding gene Chr8:70389817-70397939 (-)
LP/J ENSMUSG00230028874
 protein coding gene Chr8:71767867-71776016 (-)
NOD/ShiLtJ ENSMUSG00190026949
 protein coding gene Chr8:61986699-61994858 (-)
NZO/HlLtJ ENSMUSG00225046447
 protein coding gene Chr8:75189523-75197681 (-)
PWK/PhJ ENSLUMG00010027126
 protein coding gene Chr8:61840741-61848751 (-)
SPRET/EiJ ENSMSPG00010034043
 protein coding gene Chr8:63140476-63148520 (-)
WSB/EiJ ENSIUOG00005023876
 protein coding gene Chr8:62830252-62838421 (-)



Homology
more
  • Human Ortholog
    NPY5R, neuropeptide Y receptor Y5
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NPY5R, neuropeptide Y receptor Y5
  • Synonyms
    NPY5-R, NPYR5, NPYY5-R
  • Links
    NCBI Gene ID: 4889
    UniProt: Q15761

  • Chr Location
    4q32.2; chr4:163343583-163352477 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human NPY5R associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 4 alleles in 5 genetic backgrounds
    20 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show increased susceptibility to diet-induced obesity and a reduced orexigenic response to select agonists. Homozygotes for a reporter allele show mild late-onset obesity, increased adiposity, polyphagia, and exacerbated obesity parameters after chronic NPY infusion.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    55
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    692
  • Tissues
    63
  • cDNA Data
    8
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18168 NCBI Gene Model | MGI Sequence Detail 8130 C57BL/6J ±  kb
    transcript NM_001358958 RefSeq | MGI Sequence Detail 2398 ZRU/MplStud  
    polypeptide O70342 UniProt | EBI | MGI Sequence Detail 466 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 4
      cDNA 8
      Primer pair 1
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-37119
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 5
      Gene Ontology 13
      Phenotypes 23
    • Earliest
      J:43186 Matsumoto M, et al., Inactivation of a novel neuropeptide Y/peptide YY receptor gene in primate species. J Biol Chem. 1996 Nov 1;271(44):27217-20
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory