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Slc8a1 Gene Detail
Summary
  • Symbol
    Slc8a1
  • Name
    solute carrier family 8 (sodium/calcium exchanger), member 1
  • Synonyms
    D930008O12Rik, Ncx1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107956
    NCBI Gene: 20541
  • Alliance
  • Transcription Start Sites
    71 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:81680534-82045806 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 17, 51.29 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    11270 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107956
protein coding gene Chr17:81680534-82045816 (-)
129S1/SvImJ ENSMUSG00200023594
protein coding gene Chr17:77062795-77427132 (-)
A/J ENSMUSG00195026030
protein coding gene Chr17:78421099-78786470 (-)
AKR/J ENSMUSG00220013015
protein coding gene Chr17:77354439-77720158 (-)
BALB/cJ ENSMUSG00180004412
protein coding gene Chr17:78122242-78487948 (-)
C3H/HeJ ENSMUSG00175015040
protein coding gene Chr17:77373414-77739042 (-)
C57BL/6NJ ENSMUSG00215008118
protein coding gene Chr17:77108904-77479440 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021913
protein coding gene Chr17:77087248-77357903 (-)
CAST/EiJ ENSTCUG00005014818
protein coding gene Chr17:77969318-78315779 (-)
CBA/J ENSMUSG00210019702
protein coding gene Chr17:77234818-77600402 (-)
DBA/2J ENSMUSG00185012326
protein coding gene Chr17:80068379-80432818 (-)
FVB/NJ ENSMUSG00205017989
protein coding gene Chr17:77870882-78237623 (-)
JF1/MsJ ENSUMUG00000011466
protein coding gene Chr17:79833128-80185135 (-)
LP/J ENSMUSG00230018158
protein coding gene Chr17:81089580-81455288 (-)
NOD/ShiLtJ ENSMUSG00190009451
protein coding gene Chr17:77154890-77520591 (-)
NZO/HlLtJ ENSMUSG00225030344
protein coding gene Chr17:83351142-83716914 (-)
PWK/PhJ ENSLUMG00010005442
protein coding gene Chr17:77033605-77388924 (-)
SPRET/EiJ ENSMSPG00010008207
protein coding gene Chr17:77555026-77900320 (-)
WSB/EiJ ENSIUOG00005010473
protein coding gene Chr17:78057982-78408415 (-)



Homology
more
  • Human Ortholog
    SLC8A1, solute carrier family 8 member A1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC8A1, solute carrier family 8 member A1
  • Synonyms
    NCX1
  • Links
    NCBI Gene ID: 6546
    UniProt: P32418

  • Chr Location
    2p22.1; chr2:40097270-40611053 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human SLC8A1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    62 phenotypes from 7 alleles in 8 genetic backgrounds
    8 phenotypes from multigenic genotypes
    4 images
    70 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations have underdeveloped, nonbeating hearts with massive apoptosis of myocytes, a dilated pericardium and die around embryonic day 9.5. Heterozygotes exhibit altered responses to experimental cardiac pressure overload.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000054640 Ensembl Gene Model | MGI Sequence Detail 365273 C57BL/6J ±  kb
    transcript ENSMUST00000163123 Ensembl | MGI Sequence Detail 3180 Not Applicable  
    polypeptide ENSMUSP00000132809 Ensembl | MGI Sequence Detail 970 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 54
      Genomic 1
      cDNA 32
      Primer pair 19
      Other 2
      Antibodies 11

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGD-MRK-36536, MGI:2146942, MGI:2147028, MGI:2441999
    References
    more
    • Summaries
      All 180
      Developmental Gene Expression 51
      Gene Ontology 25
      Phenotypes 70
    • Earliest
      J:47389 Nicoll DA, et al., Molecular cloning and functional expression of the cardiac sarcolemmal Na(+)-Ca2+ exchanger. Science. 1990 Oct 26;250(4980):562-5
    • Latest
      J:376701 Scranton K, et al., The mechanism of action of digoxin requires the sodium-dependent inactivation of the sodium-calcium exchanger. Sci Adv. 2025 Dec 19;11(51):eady9596

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    09/08/2026
    MGI 6.24
    The Jackson Laboratory