About   Help   FAQ
Tuba1b Gene Detail
Summary
  • Symbol
    Tuba1b
  • Name
    tubulin, alpha 1B
  • Synonyms
    Tuba2
  • Feature Type
    protein coding gene
  • IDs
    MGI:107804
    NCBI Gene: 22143
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:98829310-98832271 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 55.21 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    139 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107804
 protein coding gene Chr15:98829306-98832446 (-)
129S1/SvImJ ENSMUSG00200047306
 protein coding gene Chr15:96017399-96020539 (-)
A/J ENSMUSG00195044585
 protein coding gene Chr15:95898152-95901292 (-)
AKR/J ENSMUSG00220047120
 protein coding gene Chr15:95903531-95906671 (-)
BALB/cJ ENSMUSG00180041071
 protein coding gene Chr15:95804811-95807951 (-)
C3H/HeJ ENSMUSG00175038330
 protein coding gene Chr15:96078202-96081342 (-)
C57BL/6NJ ENSMUSG00215050272
 protein coding gene Chr15:95867435-95870575 (-)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J ENSMUSG00210029280
 protein coding gene Chr15:95863107-95866247 (-)
DBA/2J ENSMUSG00185036564
 protein coding gene Chr15:95906737-95909878 (-)
FVB/NJ ENSMUSG00205004204
 protein coding gene Chr7:59971695-59973300 (-)
FVB/NJ ENSMUSG00205045145
 protein coding gene Chr15:95602874-95606015 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230035880
 protein coding gene Chr15:99241108-99244248 (-)
NOD/ShiLtJ ENSMUSG00190031281
 protein coding gene Chr15:95882583-95885722 (-)
NOD/ShiLtJ ENSMUSG00190007007
 protein coding gene Chr7:60095766-60097371 (-)
NZO/HlLtJ ENSMUSG00225042021
 protein coding gene Chr15:99504419-99507559 (-)
PWK/PhJ ENSLUMG00010041016
 protein coding gene Chr15:95573520-95576661 (-)
SPRET/EiJ ENSMSPG00010049232
 protein coding gene Chr15:97394591-97397732 (-)
WSB/EiJ ENSIUOG00005037813
 protein coding gene Chr15:95995058-95998199 (-)



Homology
more
  • Human Ortholog
    TUBA1B, tubulin alpha 1b
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TUBA1B, tubulin alpha 1b
  • Synonyms
    K-ALPHA-1
  • Links
    NCBI Gene ID: 10376
    UniProt: P68363

  • Chr Location
    12q13.12; chr12:49127782-49131397 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotype references
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    1
  • Radiation induced
    2
  • Targeted
    2
  • Genomic Mutations
    3 involving Tuba1b
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    11 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    675
  • Tissues
    29
  • cDNA Data
    24
  • Literature Summary
    9
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 22143 NCBI Gene Model | MGI Sequence Detail 2962 C57BL/6J ±  kb
transcript NM_011654 RefSeq | MGI Sequence Detail 1747 Not Specified  
polypeptide P05213 UniProt | EBI | MGI Sequence Detail 451 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 27
    cDNA 25
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-36381
References
more
  • Summaries
    All 77
    Developmental Gene Expression 9
    Diseases 1
    Gene Ontology 14
    Phenotypes 25
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory