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Dync1i1 Gene Detail
Summary
  • Symbol
    Dync1i1
  • Name
    dynein cytoplasmic 1 intermediate chain 1
  • Synonyms
    DIC, Dncic1, IC74
  • Feature Type
    protein coding gene
  • IDs
    MGI:107743
    NCBI Gene: 13426
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:5725772-6028030 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 2.26 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    8364 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107743
 protein coding gene Chr6:5725639-6028039 (+)
129S1/SvImJ ENSMUSG00200001487
 protein coding gene Chr6:2805713-3108109 (+)
A/J ENSMUSG00195001927
 protein coding gene Chr6:2687044-2989462 (+)
AKR/J ENSMUSG00220020303
 protein coding gene Chr6:2594453-2897163 (+)
BALB/cJ ENSMUSG00180001488
 protein coding gene Chr6:2822574-3124987 (+)
C3H/HeJ ENSMUSG00175007239
 protein coding gene Chr6:2651054-2953467 (+)
C57BL/6NJ ENSMUSG00215010944
 protein coding gene Chr6:2779846-3082269 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028085
 protein coding gene Chr6:2156921-2462377 (+)
CAST/EiJ ENSTCUG00005025106
 protein coding gene Chr6:2680388-2982367 (+)
CBA/J ENSMUSG00210020993
 protein coding gene Chr6:2588069-2890468 (+)
DBA/2J ENSMUSG00185024006
 protein coding gene Chr6:2783914-3088313 (+)
FVB/NJ ENSMUSG00205013856
 protein coding gene Chr6:2802486-3102850 (+)
JF1/MsJ ENSUMUG00000011024
 protein coding gene Chr6:2794295-3091699 (+)
LP/J ENSMUSG00230013386
 protein coding gene Chr6:3783597-4087971 (+)
NOD/ShiLtJ ENSMUSG00190015981
 protein coding gene Chr6:2508884-2813256 (+)
NZO/HlLtJ ENSMUSG00225017994
 protein coding gene Chr6:5617434-5919852 (+)
PWK/PhJ ENSLUMG00010023361
 protein coding gene Chr6:2582384-2879366 (+)
SPRET/EiJ ENSMSPG00010002755
 protein coding gene Chr6:2469429-2782377 (+)
WSB/EiJ ENSIUOG00005004074
 protein coding gene Chr6:2782639-3086833 (+)



Homology
more
  • Human Ortholog
    DYNC1I1, dynein cytoplasmic 1 intermediate chain 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DYNC1I1, dynein cytoplasmic 1 intermediate chain 1
  • Synonyms
    DNCI1, DNCIC1
  • Links
    NCBI Gene ID: 1780
    UniProt: O14576

  • Chr Location
    7q21.3; chr7:95772459-96110322 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1151
  • Tissues
    105
  • cDNA Data
    22
  • Literature Summary
    22
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 13426 NCBI Gene Model | MGI Sequence Detail 302259 C57BL/6J ±  kb
transcript NM_001409609 RefSeq | MGI Sequence Detail 2775 ZRU/MplStud  
polypeptide O88485 UniProt | EBI | MGI Sequence Detail 628 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000006771 cytoplasmic dynein 1 intermediate chain 1
    (term hierarchy)
  • InterPro Domains
    IPR025956 Cytoplasmic dynein 1 intermediate chain 1/2
    IPR050687 Dynein axonemal intermediate chain 1/2/3/4
    IPR001680 WD40 repeat
    IPR036322 WD40-repeat-containing domain superfamily
    IPR015943 WD40/YVTN repeat-like-containing domain superfamily
  • GlyGen
    O88485 3 sites, 1 O-linked glycan (2 sites)
Molecular
Reagents
less
  • All nucleic 35
    cDNA 23
    Primer pair 11
    Other 1
    Antibodies 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-36319
References
more
  • Summaries
    All 77
    Developmental Gene Expression 22
    Gene Ontology 15
    Phenotypes 8
  • Earliest
    J:34934 Vaughan KT, et al., Multiple mouse chromosomal loci for dynein-based motility. Genomics. 1996 Aug 15;36(1):29-38
  • Latest
    J:375047 Xie MX, et al., Histone lactylation regulates DOCK4 to control heat nociception and supports Dynein-mediated Nav1.7 trafficking. Nat Commun. 2025 Aug 4;16(1):7165
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory