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Plxna3 Gene Detail
Summary
  • Symbol
    Plxna3
  • Name
    plexin A3
  • Synonyms
    PlexA3, Plxa3, Plxn3, Plxn4, SEX
  • Feature Type
    protein coding gene
  • IDs
    MGI:107683
    NCBI Gene: 18846
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:73372672-73388295 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 38.00 cM, cytoband B-C1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    236 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107683
 protein coding gene ChrX:73372644-73388295 (+)
129S1/SvImJ ENSMUSG00200040329
 protein coding gene ChrX:55433402-55449227 (+)
A/J ENSMUSG00195031592
 protein coding gene ChrX:59109052-59124882 (+)
AKR/J ENSMUSG00220045628
 protein coding gene ChrX:54411364-54427194 (+)
BALB/cJ ENSMUSG00180047600
 protein coding gene ChrX:55689796-55705626 (+)
C3H/HeJ ENSMUSG00175029431
 protein coding gene ChrX:59273404-59289233 (+)
C57BL/6NJ ENSMUSG00215040257
 protein coding gene ChrX:55774013-55789840 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033182
 protein coding gene ChrX:69379596-69395235 (+)
CAST/EiJ ENSTCUG00005037439
 protein coding gene ChrX:57186431-57202245 (+)
CBA/J ENSMUSG00210040187
 protein coding gene ChrX:55954097-55969926 (+)
DBA/2J ENSMUSG00185034502
 protein coding gene ChrX:68375841-68391668 (+)
FVB/NJ ENSMUSG00205034257
 protein coding gene ChrX:55255105-55270938 (+)
JF1/MsJ ENSUMUG00000032840
 protein coding gene ChrX:89111426-89127240 (+)
LP/J ENSMUSG00230033759
 protein coding gene ChrX:74955531-74971356 (+)
NOD/ShiLtJ ENSMUSG00190029011
 protein coding gene ChrX:55194050-55209879 (+)
NZO/HlLtJ ENSMUSG00225048325
 protein coding gene ChrX:80159928-80175753 (+)
PWK/PhJ ENSLUMG00010042447
 protein coding gene ChrX:54932882-54948691 (+)
SPRET/EiJ ENSMSPG00010034367
 protein coding gene ChrX:58018051-58033879 (+)
WSB/EiJ ENSIUOG00005048488
 protein coding gene ChrX:56021790-56037613 (+)



Homology
more
  • Human Ortholog
    PLXNA3, plexin A3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLXNA3, plexin A3
  • Synonyms
    6.3, HSSEXGENE, PLXN3, PLXN4, XAP-6
  • Links
    NCBI Gene ID: 55558
    UniProt: P51805

  • Chr Location
    Xq28; chrX:154458280-154477779 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 2 genetic backgrounds
    11 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene possess misdirected axons in the hippocampus. They are, otherwise, indistinguishable from wild-type mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1123
  • Tissues
    369
  • cDNA Data
    81
  • Literature Summary
    50
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031398 Ensembl Gene Model | MGI Sequence Detail 15624 C57BL/6J ±  kb
    transcript ENSMUST00000004326 Ensembl | MGI Sequence Detail 6943 Not Applicable  
    polypeptide ENSMUSP00000004326 Ensembl | MGI Sequence Detail 1872 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 99
      Genomic 1
      cDNA 84
      Primer pair 4
      Other 10
      Antibodies 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-36258, MGD-MRK-39626, MGI:109627
    References
    more
    • Summaries
      All 99
      Developmental Gene Expression 50
      Gene Ontology 9
      Phenotypes 29
    • Earliest
      J:26634 Rivella S, et al., A comparative transcriptional map of a region of 250 kb on the human and mouse X chromosome between the G6PD and the FLN1 genes. Genomics. 1995 Aug 10;28(3):377-82
    • Latest
      J:369706 Gu Z, et al., Axon Fasciculation, Mediated by Transmembrane Semaphorins, Is Critical for the Establishment of Segmental Specificity of Corticospinal Circuits. J Neurosci. 2023 Aug 9;43(32):5753-5768
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory