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Akr1b8 Gene Detail
Summary
  • Symbol
    Akr1b8
  • Name
    aldo-keto reductase family 1, member B8
  • Synonyms
    Fgfrp, Fgrp
  • Feature Type
    protein coding gene
  • IDs
    MGI:107673
    NCBI Gene: 14187
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:34331081-34345396 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 14.91 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    551 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107673
 protein coding gene Chr6:34331054-34345398 (+)
129S1/SvImJ ENSMUSG00200044701
 protein coding gene Chr6:31383799-31398139 (+)
A/J ENSMUSG00195036248
 protein coding gene Chr6:31356167-31370511 (+)
AKR/J ENSMUSG00220008195
 protein coding gene Chr6:30957543-30971889 (+)
BALB/cJ ENSMUSG00180036519
 protein coding gene Chr6:31487830-31502174 (+)
C3H/HeJ ENSMUSG00175044482
 protein coding gene Chr6:31352497-31366841 (+)
C57BL/6NJ ENSMUSG00215043072
 protein coding gene Chr6:31385473-31399817 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028205
 protein coding gene Chr6:29137462-29151658 (+)
CAST/EiJ ENSTCUG00005025062
 protein coding gene Chr6:30932991-30946874 (+)
CBA/J ENSMUSG00210048605
 protein coding gene Chr6:31386098-31400442 (+)
DBA/2J ENSMUSG00185040938
 protein coding gene Chr6:31466313-31480657 (+)
FVB/NJ ENSMUSG00205048210
 protein coding gene Chr6:31435108-31449513 (+)
JF1/MsJ ENSUMUG00000017175
 protein coding gene Chr6:31167361-31182095 (+)
LP/J ENSMUSG00230042833
 protein coding gene Chr6:32400102-32414442 (+)
NOD/ShiLtJ ENSMUSG00190030068
 protein coding gene Chr6:31240390-31254734 (+)
NZO/HlLtJ ENSMUSG00225008645
 protein coding gene Chr6:34370522-34384866 (+)
PWK/PhJ ENSLUMG00010040161
 protein coding gene Chr6:30923427-30938115 (+)
SPRET/EiJ no annotation
WSB/EiJ ENSIUOG00005027321
 protein coding gene Chr6:31529300-31543705 (+)



Homology
more
  • Human Ortholog
    AKR1B10, aldo-keto reductase family 1 member B10
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AKR1B10, aldo-keto reductase family 1 member B10
  • Synonyms
    AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, HSI
  • Links
    NCBI Gene ID: 57016
    UniProt: O60218

  • Chr Location
    7q33; chr7:134527567-134541412 (+)  GRCh38
  • Human Ortholog
    AKR1B15, aldo-keto reductase family 1 member B15
  • Synonyms
    AKR1B10L, AKR1B10L, AK1R1B7, AKR1R1B7
  • Links
    NCBI Gene ID: 441282
    UniProt: C9JRZ8

  • Chr Location
    7q33; chr7:134549110-134579875 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice with a knock-out allele exhibit shorter colon crypts, reduced proliferation and maturation of crypt cells, elevated levels of cytokines in the colon mucosa and increased susceptibility to induced colitis and colitis-associated tumorigenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    826
  • Tissues
    130
  • cDNA Data
    51
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14187 NCBI Gene Model | MGI Sequence Detail 14316 C57BL/6J ±  kb
    transcript NM_008012 RefSeq | MGI Sequence Detail 1329 ZRU/MplStud  
    polypeptide P45377 UniProt | EBI | MGI Sequence Detail 316 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 56
      Genomic 3
      cDNA 51
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-33600, MGD-MRK-36248
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 7
      Gene Ontology 7
      Phenotypes 15
    • Earliest
      J:17208 Donohue PJ, et al., A delayed-early gene activated by fibroblast growth factor-1 encodes a protein related to aldose reductase. J Biol Chem. 1994 Mar 18;269(11):8604-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory