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Ro60 Gene Detail
Summary
  • Symbol
    Ro60
  • Name
    Ro60, Y RNA binding protein
  • Synonyms
    1810007I17Rik, A530054J02Rik, Ssa, Ssa2, SS-A/Ro, Trove2
  • Feature Type
    protein coding gene
  • IDs
    MGI:106652
    NCBI Gene: 20822
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:143626528-143652794 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 62.54 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    807 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106652
 protein coding gene Chr1:143626528-143652806 (-)
129S1/SvImJ ENSMUSG00200007660
 protein coding gene Chr1:141103525-141130011 (-)
A/J ENSMUSG00195016327
 protein coding gene Chr1:140416341-140441974 (-)
AKR/J ENSMUSG00220002762
 protein coding gene Chr1:140189639-140215268 (-)
BALB/cJ ENSMUSG00180011231
 protein coding gene Chr1:140630853-140657133 (-)
C3H/HeJ ENSMUSG00175006603
 protein coding gene Chr1:140615685-140641315 (-)
C57BL/6NJ ENSMUSG00215013178
 protein coding gene Chr1:140560228-140586506 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014676
 protein coding gene Chr1:135011598-135038074 (-)
CAST/EiJ ENSTCUG00005013209
 protein coding gene Chr1:139397596-139423915 (-)
CBA/J ENSMUSG00210013840
 protein coding gene Chr1:140577698-140603331 (-)
DBA/2J ENSMUSG00185006873
 protein coding gene Chr1:144879482-144905760 (-)
FVB/NJ ENSMUSG00205002242
 protein coding gene Chr1:139792510-139818142 (-)
JF1/MsJ ENSUMUG00000011450
 protein coding gene Chr1:144195554-144222058 (-)
LP/J ENSMUSG00230000356
 protein coding gene Chr1:144392942-144419220 (-)
NOD/ShiLtJ ENSMUSG00190002790
 protein coding gene Chr1:140391526-140417798 (-)
NZO/HlLtJ ENSMUSG00225000078
 protein coding gene Chr1:148162199-148188684 (-)
PWK/PhJ ENSLUMG00010001912
 protein coding gene Chr1:139514231-139540746 (-)
SPRET/EiJ ENSMSPG00010012077
 protein coding gene Chr1:142408867-142429354 (-)
WSB/EiJ ENSIUOG00005028557
 protein coding gene Chr1:139926215-139952494 (-)



Homology
more
  • Human Ortholog
    RO60, Ro60, Y RNA binding protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RO60, Ro60, Y RNA binding protein
  • Synonyms
    RORNP, SSA2, TROVE2
  • Links
    NCBI Gene ID: 6738
    UniProt: P10155

  • Chr Location
    1q31.2; chr1:193059445-193091777 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ro60 mouse models

Human Disease Mouse Models
      
IDs
 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 2 genetic backgrounds
    1 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice develop symptoms similar to those observed in patients with lupus, including increased photosensitivity and membranoproliferative glomerulonephritis. The production of autoantibodies is detected in both homozygous and heterozygous mutant mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    599
  • Tissues
    2
  • cDNA Data
    77
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20822 NCBI Gene Model | MGI Sequence Detail 26267 C57BL/6J ±  kb
    transcript NM_013835 RefSeq | MGI Sequence Detail 8736 ZRU/MplStud  
    polypeptide O08848 UniProt | EBI | MGI Sequence Detail 538 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 77
      cDNA 77

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-14606, MGD-MRK-35110, MGI:1916306, MGI:2138306, MGI:2443501, MGI:6276289
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 11
      Phenotypes 13
    • Earliest
      J:32812 Keech CL, et al., Structural differences between the human and mouse 52-kD Ro autoantigens associated with poorly conserved autoantibody activity across species. Clin Exp Immunol. 1996 May;104(2):255-63
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory