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Rhoc Gene Detail
Summary
  • Symbol
    Rhoc
  • Name
    ras homolog family member C
  • Synonyms
    Arh9, Arhc
  • Feature Type
    protein coding gene
  • IDs
    MGI:106028
    NCBI Gene: 11853
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:104696350-104701775 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 45.86 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    174 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106028
 protein coding gene Chr3:104695691-104701775 (+)
129S1/SvImJ ENSMUSG00200033155
 protein coding gene Chr3:101299424-101305515 (+)
A/J ENSMUSG00195024361
 protein coding gene Chr3:101727862-101733948 (+)
AKR/J ENSMUSG00220033500
 protein coding gene Chr3:100079786-100085869 (+)
BALB/cJ ENSMUSG00180016246
 protein coding gene Chr3:101654285-101660370 (+)
C3H/HeJ ENSMUSG00175026522
 protein coding gene Chr3:101208247-101214330 (+)
C57BL/6NJ ENSMUSG00215027650
 protein coding gene Chr3:101966559-101972644 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025466
 protein coding gene Chr3:98840768-98847128 (+)
CAST/EiJ ENSTCUG00005018076
 protein coding gene Chr3:101924602-101930676 (+)
CBA/J ENSMUSG00210007399
 protein coding gene Chr3:101830267-101836353 (+)
DBA/2J ENSMUSG00185021725
 protein coding gene Chr3:102302650-102308734 (+)
FVB/NJ ENSMUSG00205014015
 protein coding gene Chr3:100883972-100890062 (+)
JF1/MsJ ENSUMUG00000038679
 protein coding gene Chr3:101038423-101044492 (+)
LP/J ENSMUSG00230012486
 protein coding gene Chr3:104227359-104233450 (+)
NOD/ShiLtJ ENSMUSG00190028498
 protein coding gene Chr3:102506254-102512338 (+)
NZO/HlLtJ ENSMUSG00225019782
 protein coding gene Chr3:106693896-106699654 (+)
PWK/PhJ ENSLUMG00010028706
 protein coding gene Chr3:101122430-101128492 (+)
SPRET/EiJ ENSMSPG00010028139
 protein coding gene Chr3:101300699-101306708 (+)
WSB/EiJ ENSIUOG00005004164
 protein coding gene Chr3:101847542-101853643 (+)



Homology
more
  • Human Ortholog
    RHOC, ras homolog family member C
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RHOC, ras homolog family member C
  • Synonyms
    ARH9, ARHC, H9, RHOH9
  • Links
    NCBI Gene ID: 389
    UniProt: P08134

  • Chr Location
    1p13.2; chr1:112701127-112707845 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutation in this gene results in no abnormal phenotype, except for reduced stress fiber formation in serum starved fibroblasts. However, in combination with Tg(MMTV-PyVT)634Mul mice, metastatic potential of tumors and tumor cell motility are decreased.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    602
  • Tissues
    2
  • cDNA Data
    137
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 11853 NCBI Gene Model | MGI Sequence Detail 5426 C57BL/6J ±  kb
transcript NM_001291859 RefSeq | MGI Sequence Detail 1092 C57BL/6  
polypeptide Q62159 UniProt | EBI | MGI Sequence Detail 193 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 137
    cDNA 137
    Antibodies 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-33711, MGI:2139675
References
more
  • Summaries
    All 68
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 13
    Phenotypes 15
  • Earliest
    J:4309 Miki T, et al., Oncogene ect2 is related to regulators of small GTP-binding proteins [published erratum appears in Nature 1993 Aug 19;364(6439):737]. Nature. 1993 Apr 1;362(6419):462-5
  • Latest
    J:378551 Raghuram N, et al., Elevated expression of wildtype RhoC promotes ErbB2- and Pik3ca-induced mammary tumor formation. Breast Cancer Res. 2024 May 28;26(1):86
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory