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St8sia3 Gene Detail
Summary
  • Symbol
    St8sia3
  • Name
    ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
  • Synonyms
    Siat8c, ST8SiaIII
  • Feature Type
    protein coding gene
  • IDs
    MGI:106019
    NCBI Gene: 20451
  • Alliance
    genome feature page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:64387430-64409217 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 37.25 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    656 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106019
 protein coding gene Chr18:64387430-64412682 (+)
129S1/SvImJ ENSMUSG00200022741
 protein coding gene Chr18:61568772-61593992 (+)
A/J ENSMUSG00195031333
 protein coding gene Chr18:61619657-61645565 (+)
AKR/J ENSMUSG00220022761
 protein coding gene Chr18:61583908-61609853 (+)
BALB/cJ ENSMUSG00180011041
 protein coding gene Chr18:62186607-62212515 (+)
C3H/HeJ ENSMUSG00175009963
 protein coding gene Chr18:61791051-61816958 (+)
C57BL/6NJ ENSMUSG00215010296
 protein coding gene Chr18:61126263-61151518 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022345
 protein coding gene Chr18:60970896-60992925 (+)
CAST/EiJ ENSTCUG00005015369
 protein coding gene Chr18:60785680-60811530 (+)
CBA/J ENSMUSG00210027434
 protein coding gene Chr18:61749043-61774946 (+)
DBA/2J ENSMUSG00185028357
 protein coding gene Chr18:61653695-61678948 (+)
FVB/NJ ENSMUSG00205009723
 protein coding gene Chr18:61125310-61151238 (+)
JF1/MsJ ENSUMUG00000040544
 protein coding gene Chr18:61540815-61566718 (+)
LP/J ENSMUSG00230036392
 protein coding gene Chr18:63708287-63733507 (+)
NOD/ShiLtJ ENSMUSG00190008011
 protein coding gene Chr18:61382866-61408802 (+)
NZO/HlLtJ ENSMUSG00225029791
 protein coding gene Chr18:63598503-63623725 (+)
PWK/PhJ ENSLUMG00010023249
 protein coding gene Chr18:61949160-61975118 (+)
SPRET/EiJ ENSMSPG00010001254
 protein coding gene Chr18:88708327-88723586 (+)
WSB/EiJ ENSIUOG00005005203
 protein coding gene Chr18:61183539-61209440 (+)



Homology
more
  • Human Ortholog
    ST8SIA3, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ST8SIA3, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
  • Synonyms
    SIAT8C, ST8SiaIII
  • Links
    NCBI Gene ID: 51046
    UniProt: O43173

  • Chr Location
    18q21.31; chr18:57352557-57371731 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 3 alleles in 3 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout affects sialylation of N- and O-glycans in the striatum.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    634
  • Tissues
    20
  • cDNA Data
    42
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20451 NCBI Gene Model | MGI Sequence Detail 21788 C57BL/6J ±  kb
transcript NM_009182 RefSeq | MGI Sequence Detail 6306 C57BL/6  
polypeptide Q64689 UniProt | EBI | MGI Sequence Detail 380 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 45
    Genomic 1
    cDNA 42
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-33701, MGI:2147270
References
more
  • Summaries
    All 42
    Developmental Gene Expression 5
    Gene Ontology 11
    Phenotypes 4
  • Earliest
    J:26814 Yoshida Y, et al., Molecular cloning of Sia alpha 2,3Gal beta 1,4GlcNAc alpha 2,8-sialyltransferase from mouse brain. J Biol Chem. 1995 Jun 16;270(24):14628-33
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory