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Fer Gene Detail
Summary
  • Symbol
    Fer
  • Name
    FER tyrosine kinase
  • Synonyms
    C330004K01Rik, Fert, Fert2
  • Feature Type
    protein coding gene
  • IDs
    MGI:105917
    NCBI Gene: 14158
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:64170057-64446491 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 33.06 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7663 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105917
 protein coding gene Chr17:64136945-64453515 (+)
129S1/SvImJ ENSMUSG00200015879
 protein coding gene Chr17:59550938-59804818 (+)
A/J ENSMUSG00195015624
 protein coding gene Chr17:60879965-61133753 (+)
AKR/J ENSMUSG00220013212
 protein coding gene Chr17:59960842-60214611 (+)
BALB/cJ ENSMUSG00180017488
 protein coding gene Chr17:60623882-60877677 (+)
C3H/HeJ ENSMUSG00175006641
 protein coding gene Chr17:59940813-60194562 (+)
C57BL/6NJ ENSMUSG00215005447
 protein coding gene Chr17:59589881-59843638 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021823
 protein coding gene Chr17:60099612-60368603 (+)
CAST/EiJ ENSTCUG00005026350
 protein coding gene Chr17:60548894-60816825 (+)
CBA/J ENSMUSG00210027430
 protein coding gene Chr17:59733092-59986856 (+)
DBA/2J ENSMUSG00185022632
 protein coding gene Chr17:62573859-62827595 (+)
FVB/NJ ENSMUSG00205006564
 protein coding gene Chr17:60212857-60466608 (+)
JF1/MsJ ENSUMUG00000027716
 protein coding gene Chr17:62237154-62493237 (+)
LP/J ENSMUSG00230014981
 protein coding gene Chr17:63562960-63816711 (+)
NOD/ShiLtJ ENSMUSG00190009902
 protein coding gene Chr17:59710523-59964340 (+)
NZO/HlLtJ ENSMUSG00225025635
 protein coding gene Chr17:65829923-66083841 (+)
PWK/PhJ ENSLUMG00010008509
 protein coding gene Chr17:59495938-59756516 (+)
SPRET/EiJ ENSMSPG00010005733
 protein coding gene Chr17:59843117-60131983 (+)
WSB/EiJ ENSIUOG00005021242
 protein coding gene Chr17:60550716-60812897 (+)



Homology
more
  • Human Ortholog
    FER, FER tyrosine kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FER, FER tyrosine kinase
  • Synonyms
    p94-Fer, PPP1R74, TYK3
  • Links
    NCBI Gene ID: 2241
    UniProt: P16591

  • Chr Location
    5q21.3; chr5:108747841-109196841 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 3 alleles in 2 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted mutation exhibit elevated lipopolysaccharide-induced leukocyte adhesion and migration. Mutant cells also exhibit reduced phosphorylation of cortactin.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    117
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    639
  • Tissues
    28
  • cDNA Data
    16
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000127 Ensembl Gene Model | MGI Sequence Detail 276435 C57BL/6J ±  kb
    transcript ENSMUST00000000129 Ensembl | MGI Sequence Detail 2973 Not Applicable  
    polypeptide ENSMUSP00000000129 Ensembl | MGI Sequence Detail 823 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 16
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-33594, MGD-MRK-9756, MGD-MRK-9757, MGI:1924790, MGI:2147017
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 2
      Gene Ontology 19
      Phenotypes 22
    • Earliest
      J:10171 Fischman K, et al., A murine fer testis-specific transcript (ferT) encodes a truncated Fer protein. Mol Cell Biol. 1990 Jan;10(1):146-53
    • Latest
      J:389746 Zhang L, et al., Bcl11a orchestrates multilineage integrity in aging hematopoiesis by regulating multipotent progenitor fate decisions. Cell Rep. 2026 Jul 20;45(7):117716
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory