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Slc1a5 Gene Detail
Summary
  • Symbol
    Slc1a5
  • Name
    solute carrier family 1 (neutral amino acid transporter), member 5
  • Synonyms
    ASCT2
  • Feature Type
    protein coding gene
  • IDs
    MGI:105305
    NCBI Gene: 20514
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:16515265-16532199 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 9.15 cM, cytoband A2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    598 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105305
 protein coding gene Chr7:16515259-16532199 (+)
129S1/SvImJ ENSMUSG00200038456
 protein coding gene Chr7:9892912-9909935 (+)
A/J ENSMUSG00195051815
 protein coding gene Chr7:10357764-10374728 (+)
AKR/J ENSMUSG00220024214
 protein coding gene Chr7:8650465-8667415 (+)
BALB/cJ ENSMUSG00180048801
 protein coding gene Chr7:10273583-10290549 (+)
C3H/HeJ ENSMUSG00175049423
 protein coding gene Chr7:10757694-10774703 (+)
C57BL/6NJ ENSMUSG00215040030
 protein coding gene Chr7:10013990-10030934 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029240
 protein coding gene Chr7:15795531-15812619 (+)
CAST/EiJ ENSTCUG00005049768
 protein coding gene Chr7:10760306-10778015 (+)
CBA/J ENSMUSG00210033655
 protein coding gene Chr7:9984712-10001721 (+)
DBA/2J ENSMUSG00185051379
 protein coding gene Chr7:13499684-13516628 (+)
FVB/NJ ENSMUSG00205050987
 protein coding gene Chr7:10384025-10401009 (+)
JF1/MsJ ENSUMUG00000019349
 protein coding gene Chr7:16782559-16800260 (+)
LP/J ENSMUSG00230042527
 protein coding gene Chr7:17717311-17734827 (+)
NOD/ShiLtJ ENSMUSG00190042372
 protein coding gene Chr7:6818916-6836035 (+)
NZO/HlLtJ ENSMUSG00225053773
 protein coding gene Chr7:14953904-14970836 (+)
PWK/PhJ ENSLUMG00010050245
 protein coding gene Chr7:13070885-13088052 (+)
SPRET/EiJ ENSMSPG00010042695
 protein coding gene Chr7:9529455-9547250 (+)
WSB/EiJ ENSIUOG00005052948
 protein coding gene Chr7:15701157-15718096 (-)



Homology
more
  • Human Ortholog
    SLC1A5, solute carrier family 1 member 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC1A5, solute carrier family 1 member 5
  • Synonyms
    AAAT, ASCT2, ATBO, M7V1, M7VS1, R16, RDRC
  • Links
    NCBI Gene ID: 6510
    UniProt: Q15758

  • Chr Location
    19q13.32; chr19:46774883-46788617 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced B cells, CD4+ memory T cells in older mice, Th1 and Th17 T cells, susceptibility to EAE and T cell uptake of glutamine and leucine.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    45
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    955
  • Tissues
    132
  • cDNA Data
    111
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000001918 Ensembl Gene Model | MGI Sequence Detail 16935 C57BL/6J ±  kb
transcript ENSMUST00000108496 Ensembl | MGI Sequence Detail 2764 Not Applicable  
polypeptide ENSMUSP00000104136 Ensembl | MGI Sequence Detail 555 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000014976 neutral amino acid transporter B(0)
    (term hierarchy)
  • InterPro Domains
    IPR050746 Dicarboxylate/Amino Acid:Cation Symporter
    IPR001991 Sodium:dicarboxylate symporter
    IPR018107 Sodium:dicarboxylate symporter, conserved site
    IPR036458 Sodium:dicarboxylate symporter superfamily
  • GlyGen
    P51912 3 sites, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 113
    cDNA 111
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-32346
References
more
  • Summaries
    All 62
    Developmental Gene Expression 5
    Gene Ontology 12
    Phenotypes 10
  • Earliest
    J:24181 Liao K, et al., Expression of a novel insulin-activated amino acid transporter gene during differentiation of 3T3-L1 preadipocytes into adipocytes. Biochem Biophys Res Commun. 1995 Mar 28;208(3):1008-15
  • Latest
    J:382752 Zhu Y, et al., SLC1A5-mediated kynurenine metabolism drives AHR-FANCD2 axis to remodel chromatin and induce T cell exhaustion in lung adenocarcinoma. Cell Commun Signal. 2026 Feb 16;24(1)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory