About   Help   FAQ
Clcn2 Gene Detail
Summary
  • Symbol
    Clcn2
  • Name
    chloride channel, voltage-sensitive 2
  • Synonyms
    Clc2, ClC-2, nmf240
  • Feature Type
    protein coding gene
  • IDs
    MGI:105061
    NCBI Gene: 12724
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:20521714-20536496 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 12.50 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    298 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105061
 protein coding gene Chr16:20521185-20536496 (-)
129S1/SvImJ ENSMUSG00200040453
 protein coding gene Chr16:17519196-17533978 (-)
A/J ENSMUSG00195030652
 protein coding gene Chr16:17077405-17092185 (-)
AKR/J ENSMUSG00220038062
 protein coding gene Chr16:17394435-17409216 (-)
BALB/cJ ENSMUSG00180033808
 protein coding gene Chr16:17318013-17332797 (-)
C3H/HeJ ENSMUSG00175046709
 protein coding gene Chr16:17463052-17477834 (-)
C57BL/6NJ ENSMUSG00215037990
 protein coding gene Chr16:17184005-17198788 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020588
 protein coding gene Chr16:17863587-17878552 (-)
CAST/EiJ ENSTCUG00005043039
 protein coding gene Chr16:17791979-17806824 (-)
CBA/J ENSMUSG00210044903
 protein coding gene Chr16:17484802-17499583 (-)
DBA/2J ENSMUSG00185028226
 protein coding gene Chr16:17423567-17438349 (-)
FVB/NJ ENSMUSG00205037867
 protein coding gene Chr16:17426321-17441105 (-)
JF1/MsJ ENSUMUG00000032467
 protein coding gene Chr16:17615811-17630623 (-)
LP/J ENSMUSG00230041466
 protein coding gene Chr16:20002812-20017594 (-)
NOD/ShiLtJ ENSMUSG00190047018
 protein coding gene Chr16:17565083-17579865 (-)
NZO/HlLtJ ENSMUSG00225037154
 protein coding gene Chr16:23248613-23263395 (-)
PWK/PhJ ENSLUMG00010037430
 protein coding gene Chr16:17442837-17457645 (-)
SPRET/EiJ ENSMSPG00010046214
 protein coding gene Chr16:17305123-17319146 (-)
WSB/EiJ ENSIUOG00005035730
 protein coding gene Chr16:17658841-17673625 (-)



Homology
more
  • Human Ortholog
    CLCN2, chloride voltage-gated channel 2
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLCN2, chloride voltage-gated channel 2
  • Synonyms
    CIC-2, clC-2, CLC2, ECA2, ECA3, EGI11, EGI3, EGMA, EJM6, EJM8, FHA2, FHII, HALD2, LKPAT
  • Links
    NCBI Gene ID: 1181
    UniProt: P51788

  • Chr Location
    3q27.1; chr3:184346185-184363274 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Clcn2 mouse models; 1 with human CLCN2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    60 phenotypes from 6 alleles in 5 genetic backgrounds
    2 phenotypes from multigenic genotypes
    2 images
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit abnormal brain morphology, male infertility, and abnormal eye morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    80
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    982
  • Tissues
    78
  • cDNA Data
    43
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022843 Ensembl Gene Model | MGI Sequence Detail 14783 C57BL/6J ±  kb
    transcript ENSMUST00000007207 Ensembl | MGI Sequence Detail 3128 Not Applicable  
    polypeptide ENSMUSP00000007207 Ensembl | MGI Sequence Detail 908 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 45
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-32100, MGI:3034882, MGI:3056296
    References
    more
    • Summaries
      All 84
      Developmental Gene Expression 9
      Diseases 2
      Gene Ontology 18
      Phenotypes 40
    • Earliest
      J:29529 Lengeling A, et al., Chloride channel 2 gene (Clc2) maps to chromosome 16 of the mouse, extending a region of conserved synteny with human chromosome 3q. Genet Res. 1995 Oct;66(2):175-8
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory