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Glg1 Gene Detail
Summary
  • Symbol
    Glg1
  • Name
    golgi apparatus protein 1
  • Synonyms
    CFR, CFR-1, ESL-1, MG-160, MG160, Selel
  • Feature Type
    protein coding gene
  • IDs
    MGI:104967
    NCBI Gene: 20340
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:111881053-111985848 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 57.98 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2023 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104967
 protein coding gene Chr8:111879916-111985848 (-)
129S1/SvImJ ENSMUSG00200014223
 protein coding gene Chr8:106185374-106290452 (-)
A/J ENSMUSG00195019041
 protein coding gene Chr8:106497977-106603069 (-)
AKR/J ENSMUSG00220014925
 protein coding gene Chr8:106640415-106745507 (-)
BALB/cJ ENSMUSG00180019077
 protein coding gene Chr8:106503048-106608110 (-)
C3H/HeJ ENSMUSG00175023229
 protein coding gene Chr8:106560297-106665363 (-)
C57BL/6NJ ENSMUSG00215033989
 protein coding gene Chr8:106163259-106268337 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031572
 protein coding gene Chr8:102249616-102358686 (-)
CAST/EiJ ENSTCUG00005032360
 protein coding gene Chr8:105914297-106019361 (-)
CBA/J ENSMUSG00210030565
 protein coding gene Chr8:106487438-106592499 (-)
DBA/2J ENSMUSG00185017629
 protein coding gene Chr8:112596548-112701620 (-)
FVB/NJ ENSMUSG00205017184
 protein coding gene Chr8:105499912-105604979 (-)
JF1/MsJ ENSUMUG00000012640
 protein coding gene Chr8:114929835-115034905 (-)
LP/J ENSMUSG00230034451
 protein coding gene Chr8:116276340-116381394 (-)
NOD/ShiLtJ ENSMUSG00190024720
 protein coding gene Chr8:106638431-106743480 (-)
NZO/HlLtJ ENSMUSG00225017788
 protein coding gene Chr8:119627026-119732097 (-)
PWK/PhJ ENSLUMG00010027797
 protein coding gene Chr8:106368959-106475962 (-)
SPRET/EiJ ENSMSPG00010039665
 protein coding gene Chr8:108488204-108591912 (-)
WSB/EiJ ENSIUOG00005029693
 protein coding gene Chr8:107324097-107429186 (-)



Homology
more
  • Human Ortholog
    GLG1, golgi glycoprotein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GLG1, golgi glycoprotein 1
  • Synonyms
    CFR-1, ESL-1, MG-160, MG160
  • Links
    NCBI Gene ID: 2734
    UniProt: Q92896

  • Chr Location
    16q23.1; chr16:74447427-74607144 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 5 alleles in 5 genetic backgrounds
    14 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice show smaller size, narrow rib cages, short and thin bony elements, and reduced chondrocyte proliferation and growth plates. Homozygotes for a gene trap allele show postnatal death, small size, distorted tails and cleft palate. Homozygotes for another gene trap allele die by E10.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    640
  • Tissues
    34
  • cDNA Data
    14
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000003316 Ensembl Gene Model | MGI Sequence Detail 104796 C57BL/6J ±  kb
    transcript ENSMUST00000169020 Ensembl | MGI Sequence Detail 7021 Not Applicable  
    polypeptide ENSMUSP00000131355 Ensembl | MGI Sequence Detail 1175 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000008025 Golgi apparatus protein 1
      (term hierarchy)
    • InterPro Domains
      IPR001893 Cysteine-rich Golgi apparatus protein 1 repeat
      IPR017873 Cysteine-rich Golgi apparatus protein 1 repeat, eukaryote
      IPR039728 Golgi apparatus protein 1
    • GlyGen
      Q61543 7 sites, 5 N-linked glycans (4 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 15
      Primer pair 1
      Other 2
      Antibodies 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-31040, MGI:2142586, MGI:2142794
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 7
      Gene Ontology 10
      Phenotypes 17
    • Earliest
      J:25676 Steegmaier M, et al., The E-selectin-ligand ESL-1 is a variant of a receptor for fibroblast growth factor. Nature. 1995 Feb 16;373(6515):615-20
    • Latest
      J:369139 Liu L, et al., SEMA3B switches axon-axon to axon-glia interactions required for unmyelinated axon envelopment and integrity. Nat Commun. 2025 Jul 1;16(1):5433
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory