Tnnt2 MGI Mouse Gene Detail - MGI:104597

Symbol

Tnnt2
Name

troponin T2, cardiac
Synonyms

cardiac TnT, cTnT, Tnt

Feature Type

protein coding gene
IDs

MGI:104597
NCBI Gene: 21956
Alliance

genome feature page
Transcription Start Sites

30 TSS

Sequence Map

Chr1:135764092-135779998 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 59.32 cM
Mapping Data

4 experiments

SNPs within 2kb

612 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104597	protein coding gene	Chr1:135763933-135780006 (+)
129S1/SvImJ	ENSMUSG00200006885	protein coding gene	Chr1:133379018-133394937 (+)
A/J	ENSMUSG00195015253	protein coding gene	Chr1:132451430-132467337 (+)
AKR/J	ENSMUSG00220047274	protein coding gene	Chr1:132342106-132357949 (+)
BALB/cJ	ENSMUSG00180011067	protein coding gene	Chr1:132992027-133007934 (+)
C3H/HeJ	ENSMUSG00175006407	protein coding gene	Chr1:132695511-132711417 (+)
C57BL/6NJ	ENSMUSG00215011100	protein coding gene	Chr1:132693881-132709787 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014645	protein coding gene	Chr1:127445423-127461111 (+)
CAST/EiJ	ENSTCUG00005028306	protein coding gene	Chr1:131624898-131640815 (+)
CBA/J	ENSMUSG00210013878	protein coding gene	Chr1:132625848-132641755 (+)
DBA/2J	ENSMUSG00185028263	protein coding gene	Chr1:137002285-137018131 (+)
FVB/NJ	ENSMUSG00205002139	protein coding gene	Chr1:131961540-131977447 (+)
JF1/MsJ	ENSUMUG00000043545	protein coding gene	Chr1:136126182-136142060 (+)
LP/J	ENSMUSG00230038283	protein coding gene	Chr1:136526673-136542579 (+)
NOD/ShiLtJ	ENSMUSG00190002646	protein coding gene	Chr1:132639891-132655799 (+)
NZO/HlLtJ	ENSMUSG00225015960	protein coding gene	Chr1:140293604-140309534 (+)
PWK/PhJ	ENSLUMG00010025597	protein coding gene	Chr1:131751000-131766865 (+)
SPRET/EiJ	ENSMSPG00010011570	protein coding gene	Chr1:134553213-134569201 (+)
WSB/EiJ	ENSIUOG00005027920	protein coding gene	Chr1:132402636-132418527 (+)

Human Ortholog

TNNT2, troponin T2, cardiac type

Vertebrate Orthologs

6

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TNNT2, troponin T2, cardiac type
Synonyms

CMD1D, CMH2, CMPD2, cTnT, LVNC6, RCM3, TnTC
Links

HGNC:11949

NCBI Gene ID: 7139

UniProt: P45379
Chr Location

1q32.1; chr1:201359002-201379773 (-) GRCh38

MGI Vertebrate Homology

Tnnt2 stringent orthology
1 human;1 mouse;1 rat;4 zebrafish
HCOP

vertebrate homology predictions: TNNT2
Gene Tree

Tnnt2

Diseases

2 with Tnnt2 mouse models; 7 with human TNNT2 associations

Human Disease

Mouse Models

dilated cardiomyopathy 1D

IDs

View 3 models

hypertrophic cardiomyopathy 2

IDs

View 5 models

dilated cardiomyopathy

IDs

familial hypertrophic cardiomyopathy

IDs

familial restrictive cardiomyopathy 3

IDs

hypertrophic cardiomyopathy

IDs

restrictive cardiomyopathy

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

8 with disease annotations

References

6 with disease annotations

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Phenotype Summary

65 phenotypes from 12 alleles in 8 genetic backgrounds
3 phenotypes from multigenic genotypes
77 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

32
Chemically induced (other)

2
Endonuclease-mediated

11
Radiation induced

1
Targeted

10
Transgenic

8
Genomic Mutations

3 involving Tnnt2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

51 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a null allele exhibit embryonic lethality during and prior to organogenesis and abnormal heart development. Mice homozygous for an allele that lacks the lysine residue at position 210 exhibit dilated cardiomyopathy.

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All GO Annotations

66
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1305
Tissues

141
cDNA Data

123
Literature Summary

293

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA TNNT2

Xenbase tnnt2

ZFIN tnnt2a

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All Sequences

108
RefSeq

36
UniProt

8
CCDS

CCDS48375.1, CCDS48376.1, CCDS48377.1, CCDS48378.1

Ensembl

ENSMUSG00000026414 (Evidence)
NCBI Gene

21956

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026414	Ensembl Gene Model \| MGI Sequence Detail	15907	C57BL/6J	± kb
transcript	ENSMUST00000179863	Ensembl \| MGI Sequence Detail	1097	Not Applicable
polypeptide	ENSMUSP00000137093	Ensembl \| MGI Sequence Detail	302	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000016509 troponin T, cardiac muscle

(term hierarchy)
PDB

6KLT, 6KLU, 9E2E, 9MO4, 9MO5, 9MO6, 9MO7, 9MO8, 9MOI, 9MOK, 9MOL, 9MOM, 9MON
InterPro Domains

IPR001978 Troponin

IPR038077 Troponin domain superfamily

IPR027707 Troponin T
GlyGen

P50752 1 site, 1 O-linked glycan (1 site)

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All nucleic 153

Genomic 1

cDNA 124

Primer pair 21

Other 7

Antibodies 28

Microarray probesets 4

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MGD-MRK-26031

Summaries

All 429

Developmental Gene Expression 293

Diseases 6

Gene Ontology 16

Phenotypes 77
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:391429 Bi W, et al., Cardiomyocyte-Specific bcl11b Knockout Causes Left Ventricular Noncompaction by Dysregulating pou3f2 and Titin. Int J Mol Sci. 2026 Aug 12;27(16)

TSS for Tnnt2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9005	Chr1:135764118-135764134 (+)	34 bp
Tssr9006	Chr1:135766148-135766161 (+)	2,063 bp
Tssr9007	Chr1:135766645-135766649 (+)	2,555 bp
Tssr9008	Chr1:135768409-135768434 (+)	4,330 bp
Tssr9009	Chr1:135768595-135768616 (+)	4,514 bp
Tssr9010	Chr1:135773139-135773150 (+)	9,053 bp
Tssr9011	Chr1:135773316-135773340 (+)	9,236 bp
Tssr9012	Chr1:135773344-135773356 (+)	9,258 bp
Tssr9013	Chr1:135773631-135773642 (+)	9,545 bp
Tssr9014	Chr1:135774433-135774468 (+)	10,359 bp
Tssr9015	Chr1:135775440-135775474 (+)	11,365 bp
Tssr225	Chr1:135775475-135775478 (+)	11,385 bp
Tssr9016	Chr1:135775711-135775726 (+)	11,627 bp
Tssr9017	Chr1:135775727-135775764 (+)	11,654 bp
Tssr9018	Chr1:135775772-135775782 (+)	11,685 bp
Tssr9019	Chr1:135775797-135775815 (+)	11,714 bp
Tssr9020	Chr1:135776543-135776586 (+)	12,473 bp
Tssr9021	Chr1:135776595-135776606 (+)	12,509 bp
Tssr9022	Chr1:135777081-135777094 (+)	12,996 bp
Tssr9023	Chr1:135777100-135777168 (+)	13,042 bp
Tssr9024	Chr1:135777194-135777204 (+)	13,107 bp
Tssr9025	Chr1:135777483-135777494 (+)	13,397 bp
Tssr9026	Chr1:135777685-135777692 (+)	13,597 bp
Tssr9027	Chr1:135777795-135777810 (+)	13,711 bp
Tssr9028	Chr1:135777835-135777848 (+)	13,750 bp
Tssr9029	Chr1:135778415-135778424 (+)	14,328 bp
Tssr9030	Chr1:135778450-135778474 (+)	14,370 bp
Tssr9031	Chr1:135778509-135778529 (+)	14,427 bp
Tssr9032	Chr1:135779092-135779116 (+)	15,012 bp
Tssr9033	Chr1:135779937-135779971 (+)	15,862 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24