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Fgl2 Gene Detail
Summary
  • Symbol
    Fgl2
  • Name
    fibrinogen-like protein 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:103266
    NCBI Gene: 14190
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:21577671-21583384 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 9.83 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    263 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103266
 protein coding gene Chr5:21577640-21583384 (+)
129S1/SvImJ ENSMUSG00200010634
 protein coding gene Chr5:17211908-17217655 (+)
A/J ENSMUSG00195039537
 protein coding gene Chr5:16697122-16702857 (+)
AKR/J ENSMUSG00220036795
 protein coding gene Chr5:16732200-16737943 (+)
BALB/cJ ENSMUSG00180023281
 protein coding gene Chr5:16543812-16549553 (+)
C3H/HeJ ENSMUSG00175027017
 protein coding gene Chr5:18505835-18511568 (+)
C57BL/6NJ ENSMUSG00215013848
 protein coding gene Chr5:17111334-17117069 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026985
 protein coding gene Chr5:16374008-16379746 (+)
CAST/EiJ ENSTCUG00005003361
 protein coding gene Chr5:16767287-16773031 (+)
CBA/J ENSMUSG00210004992
 protein coding gene Chr5:17540013-17545760 (+)
DBA/2J ENSMUSG00185016640
 protein coding gene Chr5:19022020-19027773 (+)
FVB/NJ ENSMUSG00205023044
 protein coding gene Chr5:16242699-16248438 (+)
JF1/MsJ ENSUMUG00000004079
 protein coding gene Chr5:23612551-23618294 (+)
LP/J ENSMUSG00230024180
 protein coding gene Chr5:23494249-23499994 (+)
NOD/ShiLtJ ENSMUSG00190004579
 protein coding gene Chr5:16550188-16555937 (+)
NZO/HlLtJ ENSMUSG00225008514
 protein coding gene Chr5:28885196-28890935 (+)
PWK/PhJ ENSLUMG00010035294
 protein coding gene Chr5:16647508-16653258 (+)
SPRET/EiJ ENSMSPG00010028097
 protein coding gene Chr5:17537488-17541632 (+)
WSB/EiJ ENSIUOG00005031576
 protein coding gene Chr5:19359917-19365660 (+)



Homology
more
  • Human Ortholog
    FGL2, fibrinogen like 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FGL2, fibrinogen like 2
  • Synonyms
    pT49, T49
  • Links
    NCBI Gene ID: 10875
    UniProt: Q14314

  • Chr Location
    7q11.23; chr7:77193369-77199848 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Fgl2 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 2 alleles in 4 genetic backgrounds
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice for one allele have unaltered type 1 immunity responses. Homozygous null mice for another allele show partial embryonic lethality, hemorrhage at implantation sites, decreased susceptibility to hepatitis virus infection and prolongedsurvival of heart grafts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    677
  • Tissues
    35
  • cDNA Data
    24
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14190 NCBI Gene Model | MGI Sequence Detail 5714 C57BL/6J ±  kb
    transcript NM_008013 RefSeq | MGI Sequence Detail 3769 ZRU/MplStud  
    polypeptide P12804 UniProt | EBI | MGI Sequence Detail 432 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000007509 fibroleukin
      (term hierarchy)
    • InterPro Domains
      IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
      IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
      IPR037579 Fibrinogen/angiopoietin-like
      IPR020837 Fibrinogen, conserved site
      IPR036056 Fibrinogen-like, C-terminal
    • GlyGen
      P12804 5 sites, 3 N-linked glycans (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 2
      cDNA 24
      Primer pair 2
      Antibodies 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-24145, MGI:2140850
    References
    more
    • Summaries
      All 97
      Developmental Gene Expression 5
      Diseases 2
      Gene Ontology 6
      Phenotypes 39
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:363900 Bennion KB, et al., Macrophage-derived Fgl2 dampens antitumor immunity through regulation of FcgammaRIIB+CD8+ T cells in melanoma. JCI Insight. 2025 Mar 24;10(6)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory