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Tarbp2 Gene Detail
Summary
  • Symbol
    Tarbp2
  • Name
    TARBP2, RISC loading complex RNA binding subunit
  • Synonyms
    Prbp, TRBP
  • Feature Type
    protein coding gene
  • IDs
    MGI:103027
    NCBI Gene: 21357
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:102426627-102432111 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 57.65 cM, cytoband F
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    117 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103027
 protein coding gene Chr15:102423327-102432112 (+)
129S1/SvImJ ENSMUSG00200051923
 protein coding gene Chr15:99651561-99657045 (+)
A/J ENSMUSG00195038163
 protein coding gene Chr15:99541077-99546561 (+)
AKR/J ENSMUSG00220048635
 protein coding gene Chr15:99511223-99516707 (+)
BALB/cJ ENSMUSG00180038373
 protein coding gene Chr15:99424195-99429679 (+)
C3H/HeJ ENSMUSG00175045481
 protein coding gene Chr15:99742918-99748402 (+)
C57BL/6NJ ENSMUSG00215048589
 protein coding gene Chr15:99467622-99473106 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020356
 protein coding gene Chr15:96359642-96365100 (+)
CAST/EiJ ENSTCUG00005045398
 protein coding gene Chr15:98948625-98954103 (+)
CBA/J ENSMUSG00210027499
 protein coding gene Chr15:99494104-99499588 (+)
DBA/2J ENSMUSG00185040573
 protein coding gene Chr15:99511051-99516535 (+)
FVB/NJ ENSMUSG00205041099
 protein coding gene Chr15:99215808-99221292 (+)
JF1/MsJ ENSUMUG00000048263
 protein coding gene Chr15:98972974-98978452 (+)
LP/J ENSMUSG00230005385
 protein coding gene Chr15:102872572-102878056 (+)
NOD/ShiLtJ ENSMUSG00190029507
 protein coding gene Chr15:99455914-99461398 (+)
NZO/HlLtJ ENSMUSG00225027717
 protein coding gene Chr15:103052221-103057705 (+)
PWK/PhJ ENSLUMG00010046905
 protein coding gene Chr15:99183148-99188627 (+)
SPRET/EiJ ENSMSPG00010039838
 protein coding gene Chr15:100970783-100976255 (+)
WSB/EiJ ENSIUOG00005030544
 protein coding gene Chr15:99601698-99607181 (+)



Homology
more
  • Human Ortholog
    TARBP2, TARBP2 subunit of RISC loading complex
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TARBP2, TARBP2 subunit of RISC loading complex
  • Synonyms
    LOQS, TRBP, TRBP1, TRBP2
  • Links
    NCBI Gene ID: 6895
    UniProt: Q15633

  • Chr Location
    12q13.13; chr12:53500921-53506431 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene results in lethality at weaning, decreased body weight, and male infertility associated with oligozoospermia and failure of spermiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    92
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    671
  • Tissues
    35
  • cDNA Data
    72
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023051 Ensembl Gene Model | MGI Sequence Detail 5485 C57BL/6J ±  kb
    transcript ENSMUST00000249596 Ensembl | MGI Sequence Detail 1489 Not Applicable  
    polypeptide ENSMUSP00000159805 Ensembl | MGI Sequence Detail 374 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 80
      Genomic 1
      cDNA 74
      Primer pair 4
      Other 1
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-23864, MGD-MRK-37240, MGI:108201
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 14
      Phenotypes 32
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory